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Pergolide mesylate

Generic Name: pergolide mesylate (PER-go-lide)
Brand Name: Permax

Pergolide mesylate is used for:

Treating Parkinson disease when used with levodopa/carbidopa.

Pergolide mesylate is dopamine agonist. It works by stimulating dopamine receptors in the brain.

Do NOT use pergolide mesylate if:

  • you are allergic to any ingredient in pergolide mesylate
  • you are allergic to ergot-type medicines (eg, ergotamine)

Contact your doctor or health care provider right away if any of these apply to you.

Before using pergolide mesylate:

Some medical conditions may interact with pergolide mesylate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of heart or kidney problems, irregular heartbeat, lung problems, low blood pressure, or hallucinations

Some MEDICINES MAY INTERACT with pergolide mesylate. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Butyrophenones (eg, haloperidol), metoclopramide, phenothiazines (eg, thioridazine), or thioxanthenes (eg, thiothixene) because the effectiveness of pergolide mesylate may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if pergolide mesylate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use pergolide mesylate:

Use pergolide mesylate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Pergolide mesylate may be taken with or without food.
  • If pergolide mesylate needs to be stopped or if a different medicine is added to therapy by your doctor, this will be done gradually. The risk of side effects may be increased if pergolide mesylate is suddenly stopped.
  • If you miss a dose of pergolide mesylate, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use pergolide mesylate.

Important safety information:

  • Pergolide mesylate may cause drowsiness, dizziness, or lightheadedness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to pergolide mesylate. Using pergolide mesylate alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Pergolide mesylate may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.
  • Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking pergolide mesylate. Pergolide mesylate will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
  • Neuroleptic malignant syndrome (NMS) is a potentially deadly syndrome associated with pergolide mesylate if you suddenly stop taking it or if your dose is lowered too quickly. Symptoms may include increased body heat; rigid muscles; altered mental abilities, including lack of response to your surroundings; fast or irregular heartbeat; sweating. Contact your doctor at once if any of these symptoms occur. Do not stop taking pergolide mesylate without first talking with your doctor.
  • Use pergolide mesylate with caution in the ELDERLY because they may be more sensitive to its effects, especially confusion.
  • Pergolide mesylate is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is unknown if pergolide mesylate can cause harm to the fetus. If you become pregnant while taking pergolide mesylate, discuss with your doctor the benefits and risks of using pergolide mesylate during pregnancy. It is unknown if pergolide mesylate is excreted in breast milk. Do not breast-feed while taking pergolide mesylate.

If you suddenly stop taking pergolide mesylate, you may experience WITHDRAWAL symptoms, including anxiety, muscle twitching, trembling hands and fingers, weakness, dizziness, hallucinations, nausea, vomiting, sleeplessness, lightheadedness, or seizures.

Possible side effects of pergolide mesylate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; constipation; diarrhea; difficulty sleeping; dizziness; drowsiness; dry mouth; lightheadedness; loss of appetite; nausea; pain; runny nose; stomach pain; stomach upset.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; fainting; increased jerking movements; leg or foot swelling; seeing or hearing strange things (hallucinations); severe dizziness or lightheadedness; trouble breathing; unusual weakness; unusually slow, fast, or irregular heartbeat.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately. Symptoms may include agitation; fast or irregular heartbeat; hallucinations; nausea; seizures; tingling or uncontrolled movement of the arms and legs; unusual dizziness or fainting; vomiting

Proper storage of pergolide mesylate:

Store pergolide mesylate at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep pergolide mesylate out of the reach of children and away from pets.

General information:

  • If you have any questions about pergolide mesylate, please talk with your doctor, pharmacist, or other health care provider.
  • Pergolide mesylate is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about pergolide mesylate. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: June 3, 2015

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.