Generic Name: Osimertinib (oh si mer ti nib)
Brand Name: Tagrisso
Medically reviewed on Sep 5, 2018
Uses of Osimertinib:
- It is used to treat lung cancer.
What do I need to tell my doctor BEFORE I take Osimertinib?
- If you have an allergy to osimertinib or any part of osimertinib.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you are taking any drugs that can cause a certain type of heartbeat that is not normal (prolonged QT interval). There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
- If you are breast-feeding. Do not breast-feed while you take osimertinib and for 2 weeks after your last dose.
This is not a list of all drugs or health problems that interact with osimertinib.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take osimertinib with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Osimertinib?
- Tell all of your health care providers that you take osimertinib. This includes your doctors, nurses, pharmacists, and dentists.
- You may need to have your heart checked before starting osimertinib and while taking it. This includes an ECG. Talk with your doctor.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- If you have high blood sugar (diabetes), you will need to watch your blood sugar closely. Tell your doctor if you get signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
- If you are 65 or older, use osimertinib with care. You could have more side effects.
- This medicine may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child. In both men and women, this may go back to normal but sometimes it may not. Talk with your doctor.
- If you are a man and have sex with a female who could get pregnant, protect her from pregnancy during care and for at least 4 months after stopping osimertinib. Use birth control that you can trust.
- If you are a man and your sex partner gets pregnant while you take osimertinib or within 4 months after your last dose, call your doctor right away.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant.
- If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting osimertinib. Talk with your doctor.
- Use birth control that you can trust to prevent pregnancy while taking osimertinib and for 6 weeks after your last dose.
- If you get pregnant while taking osimertinib or within 6 weeks after your last dose, call your doctor right away.
How is this medicine (Osimertinib) best taken?
Use osimertinib as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take with or without food.
- To gain the most benefit, do not miss doses.
- Keep taking osimertinib as you have been told by your doctor or other health care provider, even if you feel well.
- If you have trouble swallowing, the tablet may be mixed in 2 ounces (60 mL) of water. Do not use carbonated water or other liquids. Stir well until the tablet is in small pieces. Do not crush or heat. Swallow right away.
- After drinking, rinse the container with 4 to 8 ounces (120 to 240 mL) of water and drink right away.
- Those who have feeding tubes may use osimertinib. Use as you have been told. Flush the feeding tube after osimertinib is given.
What do I do if I miss a dose?
- Skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
- Signs of electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, seizures, not hungry, or very bad upset stomach or throwing up.
- Feeling very tired or weak.
- Change in eyesight, eye pain, or very bad eye irritation.
- If bright lights bother your eyes.
- Watery eyes.
- Very bad and sometimes deadly lung or breathing problems have happened with osimertinib. Call your doctor right away if you have lung or breathing problems like trouble breathing, shortness of breath, or a cough that is new or worse.
- Heart failure has rarely happened in people taking osimertinib. Sometimes, this has been deadly. Call your doctor right away if you have shortness of breath, a big weight gain, or swelling in the arms or legs.
- A type of abnormal heartbeat (prolonged QT interval) can happen with osimertinib. Call your doctor right away if you have a fast heartbeat, a heartbeat that does not feel normal, or if you pass out.
What are some other side effects of Osimertinib?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Loose stools (diarrhea).
- Dry skin.
- Change in nails.
- Upset stomach or throwing up.
- Not hungry.
- Hard stools (constipation).
- Mouth irritation or mouth sores.
- Feeling tired or weak.
- Signs of a common cold.
- Back pain.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Osimertinib?
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about osimertinib, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about osimertinib
- Osimertinib Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- 1 Review
- Drug class: EGFR inhibitors
Other brands: Tagrisso