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Insulin Degludec and Liraglutide

Generic Name: Insulin Degludec and Liraglutide (IN su lin de GLOO dek & lir a GLOO tide)
Brand Name: Xultophy

Medically reviewed on Sep 5, 2018

Warning

  • This medicine has been shown to cause thyroid cancer in some animals. It is not known if this happens in humans. If thyroid cancer happens, it may be deadly if not found and treated early. Call your doctor right away if you have a neck mass, trouble breathing, trouble swallowing, or have hoarseness that will not go away.
  • Do not use insulin degludec and liraglutide if you have a health problem called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), or if you or a family member have had thyroid cancer.

Uses of Insulin Degludec and Liraglutide:

See also: Basaglar
  • It is used to lower blood sugar in patients with high blood sugar (diabetes).

What do I need to tell my doctor BEFORE I take Insulin Degludec and Liraglutide?

  • If you have an allergy to insulin degludec and liraglutide or any part of insulin degludec and liraglutide.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Acidic blood problem or type 1 diabetes.
  • If you have low blood sugar.
  • If you are using insulin.
  • If you are using another drug that has the same drug in it.
  • If you are using any of these drugs: Albiglutide, dulaglutide, exenatide, or lixisenatide.
  • If you are breast-feeding. Do not breast-feed while you take insulin degludec and liraglutide.

This is not a list of all drugs or health problems that interact with insulin degludec and liraglutide.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take insulin degludec and liraglutide with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Insulin Degludec and Liraglutide?

  • Tell all of your health care providers that you take insulin degludec and liraglutide. This includes your doctors, nurses, pharmacists, and dentists.
  • Allergic reactions have happened with insulin degludec and liraglutide. Rarely, some reactions can be very bad or life-threatening. Talk with the doctor.
  • Low blood sugar may happen with insulin degludec and liraglutide. Very low blood sugar can lead to seizures, passing out, long lasting brain damage, and sometimes death. Talk with the doctor.
  • Low blood potassium may happen with insulin degludec and liraglutide. If not treated, this can lead to a heartbeat that is not normal, very bad breathing problems, and sometimes death. Talk with the doctor.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how insulin degludec and liraglutide affects you.
  • Some diabetes drugs like pioglitazone or rosiglitazone may cause heart failure or make it worse in people who already have it. Using insulin with these drugs may increase this risk. If you also take one of these drugs, talk with the doctor.
  • It may be harder to control your blood sugar during times of stress like when you have a fever, an infection, an injury, or surgery. A change in level of physical activity or exercise and a change in diet may also affect your blood sugar. Talk with your doctor.
  • Wear disease medical alert ID (identification).
  • Do not drive if your blood sugar has been low. There is a greater chance of you having a crash.
  • Check your blood sugar as you have been told by your doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Avoid drinking alcohol or taking products that have alcohol in them while taking insulin degludec and liraglutide.
  • Do not share pen or cartridge devices with another person even if the needle has been changed. Sharing these devices may pass infections from one person to another. This includes infections you may not know you have.
  • A very bad and sometimes deadly pancreas problem (pancreatitis) has happened with insulin degludec and liraglutide. Talk with your doctor.
  • Kidney problems have happened with insulin degludec and liraglutide. Sometimes, kidney problems may need to be treated in the hospital. Dialysis may also be needed. Talk with your doctor.
  • If you cannot drink liquids by mouth or if you have upset stomach, throwing up, or diarrhea that does not go away, you need to avoid getting dehydrated. Contact your doctor to find out what to do. Dehydration may lead to new or worse kidney problems.
  • If you are 65 or older, use insulin degludec and liraglutide with care. You could have more side effects.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using insulin degludec and liraglutide while you are pregnant.

How is this medicine (Insulin Degludec and Liraglutide) best taken?

Use insulin degludec and liraglutide as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as a shot into the fatty part of the skin on the top of the thigh, belly area, or upper arm.
  • If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot.
  • Follow how to use as you have been told by the doctor or read the package insert.
  • Check the pen label closely each time you use insulin degludec and liraglutide. Be sure that you know how to measure and get your dose ready. If you have any questions, call your doctor or pharmacist.
  • Take insulin degludec and liraglutide at the same time of day.
  • Take with or without food.
  • Wash your hands before and after use.
  • Move site where you give the shot each time.
  • Do not use if the solution is cloudy, leaking, or has particles.
  • Do not use if solution changes color.
  • Put the cap back on after you are done using your dose.
  • Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.
  • Attach new needle before each dose.
  • Remove all pen needle covers before injecting a dose (there may be 2). If you are not sure what type of pen needle you have or how to use it, talk with the doctor.
  • Do not mix with other liquids.
  • Do not move insulin degludec and liraglutide from the pen to a syringe or mix with other types of insulin.
  • Follow the diet and workout plan that your doctor told you about.
  • Drink lots of noncaffeine liquids after using insulin degludec and liraglutide unless told to drink less liquid by your doctor.

What do I do if I miss a dose?

  • Skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.
  • If you miss 3 days of insulin degludec and liraglutide, call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of a pancreas problem (pancreatitis) like very bad stomach pain, very bad back pain, or very bad upset stomach or throwing up.
  • Signs of gallstones like sudden pain in the upper right belly area, right shoulder area, or between the shoulder blades; yellow skin or eyes; or fever with chills.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Signs of low potassium levels like muscle pain or weakness, muscle cramps, or a heartbeat that does not feel normal.
  • Change in eyesight.
  • Dizziness or passing out.
  • Slurred speech.
  • Seizures.
  • Change in skin to thick or thin where the shot was given.
  • Mood changes.
  • Shortness of breath, a big weight gain, or swelling in the arms or legs.
  • Low blood sugar can happen. The chance of low blood sugar may be raised when insulin degludec and liraglutide is used with other drugs for high blood sugar (diabetes). Signs may be dizziness, headache, feeling sleepy, feeling weak, shaking, a fast heartbeat, confusion, hunger, or sweating. Call your doctor right away if you have any of these signs. Follow what you have been told to do if you get low blood sugar. This may include taking glucose tablets, liquid glucose, or some fruit juices.

What are some other side effects of Insulin Degludec and Liraglutide?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Nose and throat irritation.
  • Signs of a common cold.
  • Headache.
  • Upset stomach or throwing up.
  • Belly pain.
  • Gas.
  • Not hungry.
  • Loose stools (diarrhea).
  • Hard stools (constipation).
  • Weight gain.
  • Irritation where the shot is given.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Insulin Degludec and Liraglutide?

  • Store unopened pens in a refrigerator. Do not freeze.
  • Store in original container.
  • Do not use if it has been frozen.
  • After first use, store in a refrigerator or at room temperature. Protect from heat and light. Throw away any part not used after 3 weeks.
  • Take off the needle after each shot. Do not store this device with the needle on it.
  • Keep the cap on the pen when not in use.
  • Do not use if insulin degludec and liraglutide is out of date.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time insulin degludec and liraglutide is refilled. If you have any questions about insulin degludec and liraglutide, please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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