Hydrocodone and ibuprofenPronunciation
Generic Name: hydrocodone and ibuprofen (HYE-droe-KOE-done & EYE-bue-PROE-fen)
Brand Name: Examples include Reprexain and Vicoprofen
Hydrocodone and ibuprofen is used for:
Short-term treatment of pain.
Hydrocodone and ibuprofen is an opioid analgesic and nonsteroidal anti-inflammatory drug (NSAID) combination. Exactly how it works is not known. Ibuprofen may block certain substances in the body that cause inflammation. Hydrocodone may affect opiate receptors in the brain to decrease pain.
Do NOT use hydrocodone and ibuprofen if:
- you are allergic to any ingredient in hydrocodone and ibuprofen
- you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)
- you have severe kidney problems
- you have recently had or will be having bypass heart surgery
- you are in the last 3 months of pregnancy
- you have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the past 14 days
Contact your doctor or health care provider right away if any of these apply to you.
Before using hydrocodone and ibuprofen:
Some medical conditions may interact with hydrocodone and ibuprofen. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you are allergic to other narcotic medicines (eg, medicines that contain codeine, morphine, oxycodone)
- if you or a family member has a history of mental or mood problems, suicidal thoughts or attempts, or alcohol or substance abuse, or if you drink alcohol
- if you have a history of kidney, liver, or lung problems, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)
- if you have a history of swelling or fluid buildup, lupus, asthma, growths in the nose (nasal polyps), or mouth inflammation
- if you have high blood pressure, blood disorders, bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel problems, or if you are at risk for any of these problems
- if you have Addison disease, thyroid problems, an enlarged prostate, or trouble urinating
- if you have asthma or breathing problems, seizures, growths in the brain, a recent head injury, or if you have had recent surgery
- if you have poor health, dehydration or low fluid volume, or low blood sodium levels
Some MEDICINES MAY INTERACT with hydrocodone and ibuprofen. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Anticoagulants (eg, warfarin), corticosteroids (eg, prednisone), heparin, salicylates (eg, aspirin), or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of bleeding, including stomach bleeding, may be increased
- Antihistamines (eg, diphenhydramine), barbiturates (eg, phenobarbital), cimetidine, or narcotic pain medicine (eg, codeine) because the risk of excessive drowsiness or severe breathing problems may be increased
- Anticholinergics (eg, benztropine), MAOIs (eg, phenelzine), probenecid, or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of hydrocodone and ibuprofen's side effects
- Buprenorphine, butorphanol, nalbuphine, naltrexone, pentazocine, or rifampin because they may decrease hydrocodone and ibuprofen's effectiveness
- Cyclosporine, lithium, methotrexate, or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by hydrocodone and ibuprofen
- Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by hydrocodone and ibuprofen
This may not be a complete list of all interactions that may occur. Ask your health care provider if hydrocodone and ibuprofen may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use hydrocodone and ibuprofen:
Use hydrocodone and ibuprofen as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Hydrocodone and ibuprofen comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get hydrocodone and ibuprofen refilled.
- Take hydrocodone and ibuprofen by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- If you miss a dose of hydrocodone and ibuprofen and you are taking it regularly, take it as soon as possible. If it is nearing time for the next dose, do not double the dose to catch up, unless advised to do so by your health care provider. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use hydrocodone and ibuprofen.
Important safety information:
- Tell your doctor or dentist that you take hydrocodone and ibuprofen before you receive any medical or dental care, emergency care, or surgery.
- Hydrocodone and ibuprofen may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use hydrocodone and ibuprofen with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using hydrocodone and ibuprofen; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
- Hydrocodone and ibuprofen has a nonsteroidal anti-inflammatory drug (NSAID) in it. It may cause an increased risk of serious and sometimes fatal heart and blood vessel problems (eg, heart attack, stroke). The risk may be greater if you already have heart problems or if you take hydrocodone and ibuprofen for a long time. Discuss any questions or concerns with your doctor.
- Serious stomach ulcers or bleeding can occur with the use of hydrocodone and ibuprofen. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking hydrocodone and ibuprofen with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.
- Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
- A severe skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause serious health problems that may not go away and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
- A serious brain problem called aseptic meningitis has rarely happened with ibuprofen (a part of hydrocodone and ibuprofen). Call your doctor right away if bright lights bother your eyes or if you have chills; confusion; fever; rash; severe headache, nausea, or vomiting; stiff neck; or unusual drowsiness.
- Hydrocodone and ibuprofen has ibuprofen in it. Before you start any new medicine, check the label to see if it has ibuprofen in it too. If it does or you are not sure, check with your doctor or pharmacist.
- Do not take aspirin while you take hydrocodone and ibuprofen unless your doctor tells you to. If you already take aspirin for a heart or other condition, talk with your doctor about whether or not you should continue to take it with hydrocodone and ibuprofen.
- Have your blood pressure checked as you have been told by your doctor.
- Lab tests may be performed while you use hydrocodone and ibuprofen. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use hydrocodone and ibuprofen with caution in the ELDERLY; they may be more sensitive to its effects, especially stomach bleeding and kidney problems.
- PREGNANCY and BREAST-FEEDING: Hydrocodone and ibuprofen may cause harm to the fetus. Do not take it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using hydrocodone and ibuprofen while you are pregnant. Long-term use of hydrocodone and ibuprofen during pregnancy may cause dependence in the unborn baby or newborn. Discuss any questions or concerns with your doctor. It is not known if this medicine is found in breast milk. Do not breast-feed while taking hydrocodone and ibuprofen.
When used for long periods of time or at high doses, hydrocodone and ibuprofen may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if hydrocodone and ibuprofen stops working well. Do not take more than prescribed.
Some people who use hydrocodone and ibuprofen for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction.
If you suddenly stop taking hydrocodone and ibuprofen, you may experience WITHDRAWAL symptoms, including anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping.
Possible side effects of hydrocodone and ibuprofen:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Anxiety; constipation; diarrhea; dizziness; drowsiness; dry mouth; gas; headache; heartburn; increased sweating; nausea; nervousness; stomach pain; trouble sleeping; vomiting; weakness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue); bloody, black, or tarry stools; blurred vision or other eye or vision problems; chest pain; confusion; fainting; numbness of an arm or leg; one-sided weakness; severe or persistent headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; slow or shallow breathing; sudden or unexplained weight gain; swelling of hands, legs, or feet; symptoms of kidney problems (eg, not able to pass urine, change in how much urine is passed, blood in the urine, a big weight gain); symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, right-sided stomach pain, unusual nausea or tiredness, yellowing of the skin or eyes); unusual bruising or bleeding; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of hydrocodone and ibuprofen:
Store hydrocodone and ibuprofen at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep hydrocodone and ibuprofen out of the reach of children and away from pets.
- If you have any questions about hydrocodone and ibuprofen, please talk with your doctor, pharmacist, or other health care provider.
- Hydrocodone and ibuprofen is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take hydrocodone and ibuprofen or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about hydrocodone and ibuprofen. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to hydrocodone and ibuprofen. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using hydrocodone and ibuprofen.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about hydrocodone/ibuprofen
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- Drug class: narcotic analgesic combinations