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Belinostat

Generic Name: belinostat (be-LIN-oh-stat)
Brand Name: Beleodaq

Belinostat is used for:

Treating a type of cancer (peripheral T-cell lymphoma [PTCL]) in certain patients.

Belinostat is a histone deacetylase inhibitor. It works by blocking the growth of some cancer cells.

Do NOT use belinostat if:

  • you are allergic to any ingredient in belinostat
  • you have an infection

Contact your doctor or health care provider right away if any of these apply to you.

Before using belinostat:

Some medical conditions may interact with belinostat. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have nausea, vomiting, or diarrhea
  • if you have kidney problems, liver problems, or bone marrow problems (eg, anemia, low platelet levels, low white blood cell levels)
  • if you have had chemotherapy treatment

Some MEDICINES MAY INTERACT with belinostat. However, no specific interactions with belinostat are known at this time. Tell your health care provider if you are taking any other medicines.

Ask your health care provider if belinostat may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use belinostat:

Use belinostat as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with belinostat. Talk to your pharmacist if you have questions about this information.
  • Belinostat is given as an infusion at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
  • If you miss a dose of belinostat, call your doctor to find out what to do.

Ask your health care provider any questions you may have about how to use belinostat.

Important safety information:

  • Tell your doctor or dentist that you take belinostat before you receive any medical or dental care, emergency care, or surgery.
  • Belinostat may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Belinostat may lower the ability of your body to fight infection. Serious and sometimes fatal infections have happened with belinostat. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • Belinostat can cause liver problems. Sometimes, this can be fatal. Discuss any questions or concerns with your doctor.
  • Belinostat may cause a serious and possibly fatal condition called tumor lysis syndrome (TLS). Contact your doctor right away if you develop symptoms such as fast or irregular heartbeat; fainting; decreased urination; muscle weakness or cramps; nausea, vomiting, diarrhea, or loss of appetite; or sluggishness. Discuss any questions or concerns with your doctor.
  • It is common to have nausea, vomiting, and diarrhea with belinostat. Sometimes, these can be serious. If you have nausea, vomiting, or diarrhea, talk with your doctor. There may be ways to lower these side effects.
  • Lab tests may be performed while you use belinostat. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: Belinostat may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if this medicine is found in breast milk. Do not breast-feed while taking belinostat.

Possible side effects of belinostat:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; fatigue; headache; loss of appetite; nausea; pain where the infusion was given; stomach pain; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); fainting; irregular heartbeat; muscle pain, weakness, or cramping; pale skin; severe or persistent dizziness; severe or persistent nausea, vomiting, or diarrhea; shortness of breath; swelling of the hands, ankles, or feet; symptoms of infection (eg, fever, flu-like symptoms, chills, cough, sore throat, burning with urination, muscle aches, worsening skin problems); symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, right-upper stomach pain, yellowing of the skin or eyes); unusual bleeding or bruising; unusual weakness or tiredness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of belinostat:

Belinostat is handled and stored by a health care provider. You will not store it at home. Keep all medicines out of the reach of children and away from pets.

General information:

  • If you have any questions about belinostat, please talk with your doctor, pharmacist, or other health care provider.
  • Belinostat is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take belinostat or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about belinostat. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to belinostat. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using belinostat.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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