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How long does the Probuphine implant last?

Answers (1)

Official Answer by Drugs.com 1 Jun 2016

In May 2016 the FDA approved Probuphine, the first buprenorphine implant for the maintenance treatment of opioid dependence. Probuphine is for use as part of a complete opioid dependence treatment program including counseling and psychosocial support.

Buprenorphine is classified as a opioid partial agonist. Probuphine consists of four, one-inch-long rods that are implanted under the skin in the upper arm and provide a constant, low-level dose of buprenorphine for six months.

In studies, roughly two-thirds of Probuphine-treated patients had no evidence of illicit opioid use throughout the six months of treatment – similar to the number of those who responded to sublingual (under the tongue) buprenorphine alone.

Some advantages to buprenorphine intradermal implants is a longer duration of action and improved patient compliance because there is no need to remember to take a daily medicine. In addition, other dose forms of buprenorphine, such sublingual pills or buccal films may be lost, forgotten or stolen.

Probuphine implants should only be inserted and removed by a health care provider who is trained and certified through a restricted program called the Probuphine Risk Evaluation and Mitigation Strategy (REMS) program.

Probuphine is expected to be available in the summer of 2016. Contact Titan Pharmaceuticals for more information at 1-650-244-4990.

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