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Generic name: albuterol and budesonide
Dosage form: inhalation aerosol, for oral inhalation use
Drug class: Antiasthmatic combinations

Medically reviewed by Judith Stewart, BPharm. Last updated on Jan 13, 2023.

What is Airsupra?

Airsupra is a prescription combination rescue inhaler for as-needed use to reduce the risk of asthma exacerbations.

Airsupra combines two medicines, a short/rapid-acting beta2-adrenergic agonist (SABA) medicine called albuterol sulfate, and an inhaled corticosteroid (ICS) medicine called budesonide in one oral inhaler, delivered into the airways as a propelled spray.

SABA medicines such as albuterol help to relax the smooth muscles of the airways, causing the airways to widen, leading to easier breathing.

ICS medicines such as budesonide help to decrease inflammation in the lungs. Inflammation in the lungs can lead to breathing difficulties.

What is Airsupra used to treat?

Airsupra is used as needed as a rescue inhaler to treat or prevent symptoms of asthma (tightening of the airways, wheezing, cough and shortness of breath).

Airsupra is also used to help prevent sudden severe breathing problems (asthma attacks).

Airsupra is administered as a dose of 2 inhalations (puffs) as needed. Do not use more than 12 inhalations (6 doses) in a 24-hour period.

Airsupra is not to be used as maintenance treatment for asthma. If you are currently taking medicine long-term to maintain control of asthma symptoms, you should continue to take that medicine as directed by your healthcare provider.

It is not known if this medicine is safe and effective in children.

Who should not use Airsupra?

You should not use Airsupra if you:

Before using Airsupra

Before you start treatment, tell your healthcare provider about all your medical conditions, including if you:

What other drugs will affect Airsupra?

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Airsupra and certain other medicines may affect each other causing side effects.

Especially, tell your healthcare provider if you take:

Ask your healthcare provider or pharmacist for a list of these medicines, if you are not sure. Know the medicines that you take. Keep a list of them to show your healthcare provider and pharmacist each time you get a new medicine.

How should I use Airsupra?

Read the step-by-step instructions at the end of this page.

Dosing information

Usual Adult Dose for Asthma

2 actuations of albuterol 90 mcg/budesonide 80 mcg by oral inhalation as needed for asthma symptoms.

- Do not take more than 6 doses (12 inhalations) in a 24-hour period.
- Prime inhaler prior to first use. Re-prime when inhaler has not been used for more than 7 days, is dropped, or after cleaning.
- Discard when the dose counter displays 0.

- for the as-needed treatment or prevention of bronchoconstriction and to reduce the risk of exacerbations in patients with asthma 18 years of age and older.

Airsupra side effects

Airsupra can cause serious side effects, including:

Call your healthcare provider or get medical help right away if you have symptoms of any of the serious side effects listed above.

Common side effects include:

Tell your healthcare provider about any side effect that bothers you or that does not go away.

These are not all the side effects. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to AstraZeneca at 1-800-236 9933.

How should I store Airsupra?

Keep all medicines out of the reach of children and pets.

General information about the safe and effective use of Airsupra

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use this medicine for a condition for which it was not prescribed. Do not give it to other people, even if they have the same condition that you have. It may harm them.

You can ask your pharmacist or healthcare provider for information that is written for healthcare professionals.

What are the ingredients in Airsupra?

Active ingredients: micronized albuterol sulfate and micronized budesonide.
Inactive ingredients: hydrofluoroalkane (HFA 134a) and porous particles 1,2-Distearoyl-sn-glycero-3-phosphocholine (DSPC) and calcium chloride.

Instructions for Use

Before using your Airsupra inhaler

1. Write the Use by Date
Write the Use By Date (12 months after you open the foil pouch) on the actuator label using permanent ink.

2. Prime your Airsupra inhaler before first use
Take the cover off the mouthpiece by squeezing both sides of the cover while pulling it down.
Shake the inhaler well.
Hold your Airsupra inhaler facing away from you and press down firmly on the top of the puff indicator to spray 1 test-puff into the air.
Repeat the priming steps for a total of 4 test-puffs.
Shake your Airsupra inhaler before each test-puff.
Extra puffs are provided for priming. Do not skip priming.

When and how to re-prime your Airsupra inhaler
Re-prime your inhaler:

To re-prime your inhaler:

Take the cover off the mouthpiece and spray 2 test-puffs into the air.
Shake your Airsupra inhaler before each test-puff.
Shake before each test-puff.
Extra puffs are provided for priming. Do not skip priming.

How to use your inhaler – Inhaling your medicine

1. Check
Take the cover off the mouthpiece. Check the mouthpiece for foreign objects and remove objects before use.
Check inside mouthpiece.

2. Shake and Inhale
Shake well
Breathe out fully
Place the mouthpiece into your mouth and close your lips around the mouthpiece.
Start to breathe in deeply and slowly while spraying 1 puff.
Continue breathing in until you cannot anymore.
Remove the mouthpiece from your mouth. Hold your breath for as long as you can or up to 10 seconds.

3. Repeat
Immediately repeat the shake and inhale step to take a second puff.
2 puffs equals 1 dose.

4. Place the mouthpiece cover back on
Place the mouthpiece cover back on the mouthpiece.

5. Rinse
Rinse your mouth with water, if available (Do not swallow the water).

Weekly rinse – Rinsing your actuator 1 time each week

1. Remove canister.

2. Rinse through both ends
Rinse each end of the actuator with warm water for 30 seconds (60 seconds total). Shake off as much water as you can. Do not use soap. Do not dry with a towel or tissue.
Look into the mouthpiece and actuator to make sure any medicine build-up has been completely washed away. If there is any build-up, repeat the weekly rinse step 2 again.
Check inside mouthpiece and actuator.

3. Air-dry
Let the actuator air-dry, such as overnight.

4. Re-assemble and re-prime
Re-assemble Airsupra when the actuator is fully dry.
First, place the mouthpiece cover back on. After the mouthpiece cover is on, gently press the canister down into actuator. Do not insert the canister while the mouthpiece cover is off.
Re-prime the inhaler by following the Re-prime steps above.

Emergency inhaler use when wet
If you need to use the inhaler before it is dry:

Storing your inhaler

Throwing away your Airsupra inhaler

Throw away your Airsupra inhaler in the household trash:

Ordering a new Airsupra inhaler

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.