Ciprodex Side Effects

Generic Name: ciprofloxacin / dexamethasone otic

Note: This page contains information about the side effects of ciprofloxacin / dexamethasone otic. Some of the dosage forms included on this document may not apply to the brand name Ciprodex.

Not all side effects for Ciprodex may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to ciprofloxacin / dexamethasone otic: otic suspension

Along with its needed effects, ciprofloxacin / dexamethasone otic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects of ciprofloxacin / dexamethasone otic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Ear discomfort
  • ear pain
  • itching skin on the ear
  • Bitter, sour or unusual taste in mouth
  • ear congestion
  • ear debris
  • ear residue
  • redness of skin
  • superimposed ear infection (second ear infection)

For Healthcare Professionals

Applies to ciprofloxacin / dexamethasone otic: otic suspension


Local side effects in patients with intact tympanic membranes have included ear pruritus (1.5%), ear debris (0.6%), superimposed ear infection (0.6%), ear congestion (0.4%), ear pain (0.4%), ear discomfort, decreased hearing, and tingling. Ear discomfort (3%), ear pain (2.3%), and ear residue (0.5%), tube blockage, tinnitus, and ear pruritus have been reported in pediatric patients with tympanostomy tubes.


Gastrointestinal side effects have included taste perversion and oral moniliasis.

Nervous system

Nervous system side effects have included dizziness and irritability.


Dermatologic side effects have included erythema.


Other side effects in patients with tympanostomy tubes have included crying.

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