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Amphetamine / dextroamphetamine Side Effects

In Summary

Commonly reported side effects of amphetamine/dextroamphetamine include: weight loss, insomnia, headache, anorexia, and xerostomia. Other side effects include: nausea, and emotional lability. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to amphetamine / dextroamphetamine: oral capsule extended release, oral tablet

In addition to its needed effects, some unwanted effects may be caused by amphetamine / dextroamphetamine. In the event that any of these side effects do occur, they may require medical attention.

Severity: Major

You should check with your doctor immediately if any of these side effects occur when taking amphetamine / dextroamphetamine:

More common:
  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • fast, pounding, or irregular heartbeat or pulse
  • frequent urge to urinate
  • lower back or side pain
Less common:
  • Cold or flu-like symptoms
  • cough or hoarseness
  • fever or chills
Incidence not known:
  • Blistering, peeling, or loosening of the skin
  • chest pain or discomfort
  • confusion
  • convulsions
  • dark-colored urine
  • diarrhea
  • difficulty breathing
  • difficulty with speaking
  • difficulty with swallowing
  • dizziness
  • double vision
  • faintness
  • headache
  • inability to move the arms, legs, or facial muscles
  • inability to speak
  • itching
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of bladder control
  • muscle cramps or spasms
  • muscle pain or stiffness
  • muscle spasm or jerking of all extremities
  • nausea
  • pain or discomfort in the arms, jaw, back, or neck
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • seeing, hearing, or feeling things that are not there
  • skin rash
  • slow speech
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • sudden loss of consciousness
  • sweating
  • swelling of the feet or lower legs
  • tightness in the chest
  • troubled breathing
  • uncontrolled repeated movements (tics)
  • uncontrolled vocal outbursts
  • unusual tiredness or weakness
  • vomiting

Severity: Minor

Some of the side effects that can occur with amphetamine / dextroamphetamine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Anxiety
  • dry mouth
  • lack or loss of strength
  • stomach pain
  • weight loss
Incidence not known:
  • Constipation
  • decreased interest in sexual intercourse
  • false or unusual sense of well-being
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs

For Healthcare Professionals

Applies to amphetamine / dextroamphetamine: oral capsule extended release, oral tablet

Metabolic

Very common (10% or more): Appetite loss (up to 36%), weight loss (up to 10%)
Frequency not reported: Anorexia[Ref]

Gastrointestinal

Very common (10% or more): Dry mouth (up to 35%), abdominal pain (up to 14%)
Common (1% to 10%): Nausea, vomiting, diarrhea, dyspepsia
Frequency not reported: Unpleasant taste, constipation, other GI disturbances[Ref]

Cardiovascular

Very common (10% or more): Transient blood pressure elevations (up to 35%)
Common (1% to 10%): Tachycardia, palpitation
Frequency not reported: Cardiomyopathy, myocardial infarction, Raynaud's phenomenon[Ref]

Psychiatric

Very common (10% or more): Insomnia (up to 27%), nervousness (up to 13%)
Common (1% to 10%): Emotional lability, agitation, anxiety
Frequency not reported: Psychotic episodes, irritability, euphoria, dysphoria, restlessness, depression, aggression, anger, logorrhea, dermatillomania[Ref]

Nervous system

Very common (10% or more): Headache (up to 26%)
Common (1% to 10%): Somnolence, dizziness, twitching, speech disorder (e.g., stuttering, excessive speech)
Frequency not reported: Overstimulation, paresthesia/formication, dyskinesia, tremor, exacerbation of motor/phonic tics and Tourette's syndrome[Ref]

Dermatologic

Common (1% to 10%): Photosensitivity reaction, sweating
Frequency not reported: Urticaria, rash, alopecia, serious skin rashes (e.g., Stevens-Johnson Syndrome, toxic epidermal necrolysis)[Ref]

Endocrine

Common (1% to 10%): Decreased libido, dysmenorrhea, impotence
Frequency not reported: Frequent or prolonged erections[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection[Ref]

Other

Common (1% to 10%): Fever, infection, accidental injury, asthenia/fatigue, tooth disorder (e.g., teeth clenching, tooth infection)
Frequency not reported: Sudden death, bruxism[Ref]

Respiratory

Common (1% to 10%): Dyspnea[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity reactions (e.g., angioedema, anaphylaxis)[Ref]

Ocular

Frequency not reported: Blurred vision, mydriasis[Ref]

Musculoskeletal

Postmarketing reports: Rhabdomyolysis[Ref]

References

1. "Product Information. Adderall (amphetamine-dextroamphetamine)" Shire Richwood Pharmaceutical Company, Florence, KY.

2. "Product Information. Adderall XR (amphetamine-dextroamphetamine)." Shire Richwood Pharmaceutical Company Inc, Florence, KY.

Not all side effects for amphetamine / dextroamphetamine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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