Amphetamine / dextroamphetamine Pregnancy and Breastfeeding Warnings
Amphetamine / dextroamphetamine Pregnancy Warnings
Amphetamines have been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of embryotoxicity and teratogenicity. There are no controlled data in human pregnancy. There has been one report of a case of severe congenital bony deformity, tracheoesophageal fistula, and anal atresia (vater association) in a baby born to a woman using dextroamphetamine during the first trimester of pregnancy. Amphetamines should only be given during pregnancy when benefits outweigh risks.
Infants born to mothers dependent on amphetamines have an increased risk of premature delivery and low birth weight. These infants may experience symptoms of withdrawal including dysphoria, agitation, weakness, and exhaustion. One study on the affects of methamphetamine abuse on pregnancy outcome reported that body weight, length, and head circumference were significantly decreased in neonates born to mothers who abused methamphetamines during pregnancy. The study also noted that the frequency of congenital anomalies was not significantly increased.
Amphetamine / dextroamphetamine Breastfeeding Warnings
Amphetamine is excreted into human milk. Amphetamine is considered contraindicated during breast-feeding by the manufacturer.
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