Adderall Side Effects

Please note - some side effects for Adderall may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Adderall - for the Consumer

Adderall

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Adderall:

Constipation; diarrhea; difficulty sleeping; dizziness; dry mouth; headache; loss of appetite; nausea; nervousness; restlessness; stomach pain or upset; unpleasant taste; vomiting; weight loss.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; change in sexual ability or desire; chest pain; confusion; depression; fast or irregular heartbeat; fever; growth suppression; mental/mood changes; numbness or tingling in an arm or leg; one-sided weakness; painful or frequent urination; seizures; severe headache; severe stomach pain; severe weight loss; sudden severe dizziness, fainting, or vomiting; uncontrolled muscle movement; unusual weakness or tiredness; vision or speech changes.

Adderall XR Extended-Release Capsules

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Adderall XR Extended-Release Capsules:

Constipation; diarrhea; difficulty sleeping; dizziness; dry mouth; headache; loss of appetite; nausea; nervousness; restlessness; stomach pain or upset; unpleasant taste; vomiting; weight loss.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; change in sexual ability or desire; chest pain; confusion; depression; fast or irregular heartbeat; fever; growth suppression; mental/mood changes; numbness or tingling in an arm or leg; one-sided weakness; painful or frequent urination; seizures; severe headache; severe stomach pain; severe weight loss; sudden severe dizziness, fainting, or vomiting; uncontrolled muscle movement; unusual weakness or tiredness; vision or speech changes.

Adderall Side Effects - for the Professional

Adderall

Cardiovascular

Palpitations, tachycardia, elevation of blood pressure, sudden death, myocardial infarction. There have been isolated reports of cardiomyopathy associated with chronic amphetamine use.

Central Nervous System

Psychotic episodes at recommended doses, overstimulation, restlessness, dizziness, insomnia, euphoria, dyskinesia, dysphoria, depression, tremor, headache, exacerbation of motor and phonic tics and Tourette's syndrome, seizures, stroke.

Gastrointestinal

Dryness of the mouth, unpleasant taste, diarrhea, constipation, other gastrointestinal disturbances. Anorexia and weight loss may occur as undesirable effects.

Allergic

Urticaria, rash, rare reports of angioedema, rare reports of a symptom complex resembling anaphylaxis.

Endocrine

Impotence, changes in libido.

Side Effects by Body System

Gastrointestinal

Gastrointestinal side effects have included dry mouth (35%), loss of appetite (33%), nausea (8%), diarrhea (6%), unpleasant taste, constipation, (undesired) anorexia, weight loss, and other disturbances.

Nervous system

Nervous system side effects have included insomnia (27%), agitation (8%), anxiety (8%), dizziness (7%), depression, seizures, stroke, overstimulation, restlessness, euphoria, dyskinesia, dysphoria, tremor, headache, exacerbation of motor and phonic tics, and Tourette's syndrome.

It is unclear whether CNS stimulant drugs (i.e., dextroamphetamine, methylphenidate, amphetamine-dextroamphetamine) have a role in either the development or worsening of tic disorders such as Tourette's syndrome. According to several case reports, use of CNS stimulant medications may have precipitated or exacerbated tic disorders in some patients with ADHD. Based on these cases, in Tourette's-susceptible patients, CNS stimulants may exacerbate motor and phonic tics that do not subside following discontinuation of the offending agent. In several controlled studies involving patients with ADHD and tic disorders, in the majority of patients, tics did not increase following use of CNS stimulants. In addition, controlled studies have not found that methylphenidate worsens motor tics in Tourette's syndrome nor has it increased tics in patients without Tourette's. However, it should be noted that tics were reported in 7% of patients using the methylphenidate patch compared to 1% to those taking it orally. Additional studies are required in order to clarify this association.

Metabolic

Metabolic side effects including weight loss (11%) have been reported.

Cardiovascular

Cardiovascular side effects have included tachycardia (6%), palpitations, elevated blood pressure, sudden death, and myocardial infarction. There are isolated reports of cardiomyopathy associated with chronic amphetamine use.

Genitourinary

Genitourinary side effects including urinary tract infection (5%), dysmenorrhea, and impotence have been reported.

Other

Other side effects have included a significant elevation (highest in the evening) of the plasma corticosteroid levels. Amphetamines may interfere with urinary steroid determination. Headache (26%), asthenia (6%), somnolence, infection, tooth disorder, speech disorder, and twitching have also been reported.

Dermatologic

Dermatologic side effects have included urticaria, photosensitivity reaction, and sweating.

Endocrine

Endocrine side effects have included impotence and changes in libido.

Psychiatric

Psychiatric side effects including emotional lability and psychotic episodes have been reported rarely at recommended doses.

Respiratory

Respiratory side effects including dyspnea have been reported.

Hypersensitivity

Hypersensitivity side effects have included urticaria.

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