Synovex Primer (Canada)

HOW TO IMPLANT WITH SYNOVEX PRIMER PELLETS:

Study the following instructions carefully, then proceed step by step, until the technique becomes routine. Many head can be implanted per hour by an experienced team, one member of which should be assigned to do nothing but the implantation. Hands should be kept clean and only sanitized instruments should be used.

Step 1 Loading The Implanter

Load the implanter following the directions outlined in the instruction manual accompanying each implanter.

Step 2 Restraint

The animal must be confined in a restraint mechanism (squeeze chute or head gate). The implant site on the back of the ear should be prepared by scrubbing with a generous-sized piece of cotton that has been soaked in a germicidal solution.

Note: If implanting horned cattle, greater safety is provided when the head is controlled by the use of a bull lead (nose tongs).

Step 3 Implant Site

Divide the ear into three imaginary sections as illustrated. The implanted pellets should be deposited in the center one-third of the ear as shown. To accomplish this, the implanter needle should be inserted in the outer one-third of the ear as indicated by the “X” in the illustration. Implanting too close to the head may cause abnormal sexual behavior. Care should be taken to avoid severing the major arteries of the ear.

Step 4 Insert Needle

Grasp the ear with one hand. Holding the implanter firmly with the other hand, penetrate the skin at the point shown by the “X”. Thrust the needle under the skin, taking care not to penetrate the cartilage. Ease the implanter forward (toward the base of the ear) until the full needle length is beneath the skin.

Step 5 Pellet Implantation

When the needle is completely inserted, activate the instrument by squeezing the trigger completely. Do not withdraw the needle, but allow the automatic needle retractor to release the pellets. This will allow the pellets to be deposited in a straight line in the path of the retracted needle.

Step 6 Inspection

Check the implant site. If properly administered, the implants should lie in a straight line under the skin. Disinfect the implanter needle in a germicidal solution and recock the instrument by rotating the cocking grip left, pull back, rotate right, then push all the way forward. You are now ready to implant the next animal.

CAUTIONS: SYNOVEX PRIMER is not to be used in animals intended for subsequent breeding. Implanting too close to the head may cause abnormal sexual behaviour.

Warnings

No withdrawal period is required when treated according to the label. Do not use in calves to be processed for veal. Implant pellets in ear only. Any other location may result in condemnation of the carcass. Do not attempt salvage of implanted site for human or animal food. Do not use in dairy cattle.

Keep out of reach of children.

EFFICACY: A 90-day controlled field study was conducted in four U.S. sites. The study enrolled crossbred beef steers and heifers, weighing 180 - 313 kg. Two study sites utilized steers and heifers housed in complete confinement in dirt floor pens and fed a total mixed ration. Two other sites (backgrounder conditions) utilized steers and heifers housed on dormant, mostly grazed pasture and were offered free choice hay and fed a concentrate supplement.

Descriptive statistics of Average Daily Gain (ADG) comparing the response of SYNOVEX PRIMER (T1) to the Negative Control (T0) by Housing Type

The overall implant reaction rate of Control cattle injected with an empty needle was 0.7% (4 out of 560 animals) versus 2.5% (14 out of 559 animals) for SYNOVEX PRIMER implanted cattle. Abnormal health events (mainly pink eye, respiratory disease, and lameness) were similar between the control group (19 events) and the SYNOVEX PRIMER implanted group

(16 events).

Storage

Store between 20 and 25°C with excursions between 15 and 30°C. Avoid light, excessive heat and humidity. Once the pouch is opened, the unused product should be returned to the pouch (folding its open end) and stored away from light for up to three months at 2 to 8 °C.

One box contains a single pouch holding: NET 10 cartridges of 10 doses (100 implants).

Zoetis^® and SYNOVEX are registered trademarks and SYNOVEX PRIMER is a trademark of Zoetis or its licensors.

Zoetis Canada Inc., Kirkland QC H9H 4M7

March 2025

CPN: 1198129.0