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Synovex Plus (Canada)

This page contains information on Synovex Plus for veterinary use.
The information provided typically includes the following:
  • Synovex Plus Indications
  • Warnings and cautions for Synovex Plus
  • Direction and dosage information for Synovex Plus

Synovex Plus

This treatment applies to the following species:
Company: Zoetis


trenbolone acetate and estradiol benzoate

Veterinary Use Only

DIN 02162830

SYNOVEX PLUS (trenbolone acetate and estradiol benzoate) is an implant containing 200 mg of trenbolone acetate and 28 mg of estradiol benzoate. Each implant consists of 8 pellets. Ten implants are provided in each cartridge.

INDICATIONS FOR USE: To increase weight gain and improve feed efficiency in feedlot steers and heifers.

DOSAGE: One implant (eight pellets), containing 200 mg of trenbolone acetate and 28 mg of estradiol benzoate, is administered to each animal by subcutaneous implantation in the middle one-third of the ear.

The 8 pellets which make up one dose of SYNOVEX® PLUS® are contained in one channel of the ten-dose cartridge. The ten-dose cartridge is designed to be used exclusively with a SYNOVEX implanting device.


Do not use in calves to be processed for veal. Implant pellets in ear only; any other location may result in condemnation of the carcass. Do not attempt salvage of implanted site for human or animal food. Do not use in dairy cattle.

Keep out of reach of children


CAUTIONS: SYNOVEX PLUS is not to be used in animals intended for subsequent breeding. Implanting too close to the head may cause abnormal sexual behavior.

Directions For Use

Implant complete contents of one cartridge channel per animal. Approved implantation technique is fully described on the carton foldout panel.

NOTE: Never sacrifice careful, clean technique for speed of implantation.

SYNOVEX PLUS is recommended for use in feedlot steers and heifers.

When properly administered, SYNOVEX PLUS Implants can help increase weight gain and improve feed efficiency.

HOW TO IMPLANT WITH SYNOVEX PLUS PELLETS: Study the following instructions carefully, then proceed step by step, until the technique becomes routine. Many head can be implanted per hour by an experienced team, one member of which should be assigned to do nothing but the implantation. He should keep his hands clean and use sanitary instruments only.

Step 1 Loading The Implanter

Load the implanter following the directions outlined in the instruction manual accompanying each implanter.

Step 2 Restraint

The animal must be confined in a restraint mechanism (squeeze chute or head gate). The implant site on the back of the ear should be prepared by scrubbing with a generous-sized piece of cotton that has been soaked in a germicidal solution.

Note: If implanting horned cattle, greater safety is provided when the head is controlled by the use of a bull lead (nose tongs).

Step 3 Implant Site

Divide the ear into three imaginary sections as illustrated. The implanted pellets should be deposited in the center one-third of the ear as shown. To accomplish this, the implanter needle should be inserted in the outer one-third of the ear as indicated by the “X” in the illustration. Implanting too close to the head may cause abnormal sexual behavior. Care should be taken to avoid severing the major arteries of the ear.

Step 4 Insert Needle

Just before grasping the ear with one hand, release the safety by striking the butt of the gun. Holding the implanter firmly with the other hand, penetrate the skin at the point shown by the “X”. Thrust the needle under the skin, taking care not to penetrate the cartilage. Ease the implanter forward (toward the base of the ear) until the full needle length is beneath the skin.

Step 5 Pellet Implantation

When the needle is completely inserted, activate the instrument by squeezing the trigger completely. Do not withdraw the needle, but allow the automatic needle retractor to release the pellets. This will allow the pellets to be deposited in a straight line in the path of the retracted needle.

Step 6 Inspection

Check the implant site. If properly administered, the implants should lie in a straight line under the skin.

Disinfect the implanter needle in a germicidal solution and recock the instrument by rotating the cocking grip left, pull back, rotate right, then push all the way forward. You are now ready to implant the next animal.


Store between 20 and 25°C with excursions between 15 and 30°C. Avoid light, excessive heat and humidity.

Use unopened product before the expiration date printed on the label.

Once the product container (pouch) is opened, unused product should be carefully resealed in the pouch and stored at refrigerator temperatures between 2 and 8°C for up to three months.

Zoetis is a trademark and Synovex Plus is a registered trademark of Zoetis or its licensors, used under license by Zoetis Canada Inc.

Zoetis Canada Inc., Kirkland QC H9H 4M7

One box contains a single pouch holding:

NET 10 cartridges of 10 doses (100 implants)




CPN: 1198407.3

Order Desk:   800-663-8888
Technical Services Canada:   800-461-0917
Technical Services USA:   800-366-5288
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Copyright © 2023 Animalytix LLC. Updated: 2023-05-29