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Pyramid 5

This page contains information on Pyramid 5 for veterinary use.
The information provided typically includes the following:
  • Pyramid 5 Indications
  • Warnings and cautions for Pyramid 5
  • Direction and dosage information for Pyramid 5

Pyramid 5

This treatment applies to the following species:
Company: Boehringer Ingelheim

Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Vaccine

Modified Live Virus

Veterinary Use Only


Pyramid 5 Indications

For vaccination of healthy cattle as an aid in the prevention of disease caused by bovine rhinotracheitis virus, bovine virus diarrhea (types 1 and 2), bovine parainfluenza 3, and bovine respiratory syncytial virus. A duration of immunity of 217 days has been demonstrated against respiratory disease caused by BVD type 1b. Vaccination provides a protective effect against the development of post-challenge viremia and leukopenia. This product aids in the prevention of persistent BVD type 1 and type 2 infection of the fetal calf when it is used subcutaneously in the cow or heifer 30 to 60 days pre-breeding. This vaccine may be used in pregnant cows or calves nursing pregnant cows provided the cows were vaccinated pre-breeding, according to label instructions, with any Express® FP vaccine, Pyramid 5, Pyramid 10, Pyramid 3, Pyramid 3 + Presponse SQ, or Pyramid 5 + Presponse SQ.


This product contains IBR, BVD types 1 and 2, PI3, and BRSV modified live viruses, with Metastim® adjuvant, and neomycin, polymyxin B, and thimerosal as preservatives.

Pyramid 5 Dosage And Administration

Aseptically rehydrate with the accompanying diluent. Shake well. Inject one 2 mL dose subcutaneously using aseptic technique. Annual revaccination is recommended. Protect animals from exposure for at least 14 days after vaccination. Calves vaccinated under 6 months of age should be revaccinated at 6 months of age.

Summary Of Pregnant Cow Safety Study

Safety in pregnant cows and heifers was demonstrated in trials conducted in three separate herds of more than 1,400 cows. Prior to breeding, all animals were vaccinated with Pyramid 5, a modified live virus (MLV) vaccine containing IBR, BVD types 1 & 2, PI3, and BRSV. During the first, second or third trimester of pregnancy, the animals were vaccinated again. The pregnant cows received either Pyramid 5 or a killed virus (KV) IBR, BVD types 1 & 2, PI3, and BRSV vaccine (Triangle® 5). From pregnancy vaccination through calving, the cows were observed for fetal loss. Fetal loss in both groups was similar with 0.9% in the Pyramid 5 vaccinated groups and 1.6% in the KV vaccinated groups. In addition, no abortions due to IBR or BVD were identified in either group. Following birth, each calf’s health was monitored for 30 days. The health of calves born to Pyramid 5 vaccinated dams was similar to the health of calves born to the KV vaccinated dams. Fetal health risks associated with vaccination of pregnant animals with modified live vaccines cannot be unequivocally determined by clinical trials conducted for licensure. Vaccination of pregnant animals with modified live vaccines should be discussed with a veterinarian.


Store in the dark at 35 - 45°F (2 - 7°C). Avoid freezing. Use entire contents when first opened. A small percentage of animals may show transient mild injection site swelling. Do not vaccinate within 21 days before slaughter. Burn container and all unused contents. In case of anaphylactoid reaction, administer epinephrine.

Pyramid®, Express®, and Triangle® are registered trademarks of Boehringer Ingelheim Vetmedica, Inc.

Metastim® is a trademark of Wyeth LLC. Used under license.

© 2016 Boehringer Ingelheim Vetmedica, Inc. All rights reserved.

Boehringer Ingelheim Vetmedica, Inc., St. Joseph, MO 64506

US Vet. Lic. No. 124


10 Doses/Rehydrate to 20 mL


50 Doses/Rehydrate to 100 mL


CPN: 1028246.1

Telephone:   800-325-9167
Fax:   816-236-2717
Every effort has been made to ensure the accuracy of the Pyramid 5 information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2021 Animalytix LLC. Updated: 2021-10-04