Propalin

Manufacturer: Vétoquinol USA

(phenylpropanolamine) Tablets

FOR ORAL USE IN DOGS ONLY

CAUTION: FEDERAL LAW RESTRICTS THIS DRUG TO BE USED BY OR ON THE ORDER OF A LICENSED VETERINARIAN.

Propalin Caution

Federal law restricts this drug to be used by or on the order of a licensed veterinarian.

Active Ingredient

Each chewable tablet contains either:

Phenylpropanolamine HCl 25 mg

Phenylpropanolamine HCl 50 mg

Phenylpropanolamine HCl 75 mg

How Supplied

PROPALIN™ Tablets are supplied in 60 and 180 count bottles.

Storage Conditions

Store in a dry place below 25°C (77°F). Do not refrigerate.

Propalin Indications

PROPALIN™ is recommended for the long-term management of urinary incontinence associated with urethral sphincter incompetence in spayed dogs.

Pharmacology

SYMPATHOMIMETIC AGENT

Phenylpropanolamine is a chemical analogue of the endogenous sympathomimetic amines. It is an α-adrenergic agent which has been reported to increase resting urethal tone in dogs.¹ It acts by direct stimulation of the smooth muscle of the internal urethral sphincter.

Propalin Dosage And Administration

Administer orally with food, 3 mg/kg B.W. per day, divided in 2 or 3 equal doses:

Tablets

25 Mg: For Smaller Dogs

Divided In 2 Doses

1.5 mg/kg B.W. (1 PROPALIN™ 25 mg tablet/17 kg B.W. 1/2 tablet/8.3 kg B.W.) two times daily.

Divided In 3 Doses

1.0 mg/kg B.W. (1 PROPALIN™ 25 mg tablet/25 kg B.W. 1/2 tablet/12.5 kg B.W.) three times daily.

50 Mg: For Medium Dogs

Divided In 2 Doses

1.5 mg/kg B.W. (1 PROPALIN™ 50 mg tablet/34 kg B.W. 1/2 tablet/17 kg B.W.) two times daily.

Divided In 3 Doses

1.0 mg/kg B.W. (1 PROPALIN™ 50 mg tablet/50 kg B.W. 1/2 tablet/25 kg B.W.) three times daily.

75 Mg: For Larger Dogs

Divided In 2 Doses

1.5 mg/kg B.W. (1 PROPALIN™ 75 mg tablet/50 kg B.W. 1/2 tablet/25 kg B.W.) two times daily.

Divided In 3 Doses

1.0 mg/kg B.W. (1 PROPALIN™ 75 mg tablet/75 kg B.W. 1/2 tablet/75 kg B.W.) three times daily.

If clinical response is poor, the initial diagnosis should be reconsidered.

For this drug to be effective, it must be administrated as directed. Missed doses will negate its effect.

Contraindication(s)

Do not use in animals with pre-existing medical conditions (e.g. cardiovascular disease, hypertensive disease, renal insufficiency). Do not use in animals taking cardiovascular medications or any other sympathomimetic agents.

Human Warnings

FOR ANIMAL USE ONLY. KEEP OUT OF REACH OF CHILDREN.

Adverse Reactions

Lethargy and inappetence have been reported in a dog following an overdose (2.5 mg/kg three times daily).

Side Effects

Sympathomimetics may produce a wide range of effects, most of which mimic the results of excessive stimulation of the sympathetic nervous system. Side effects include anorexia, restlessness, irritability, tremors, tachycardia, cardiac arrhythmia, hypertension and urinary retention.

Precautions

Do not exceed the recommended dose. Higher dose can result in anorexia, vomiting, tachycardia, disorientation and mydriasis.

IF ONGOING SIDE EFFECTS OR URINARY INCONTINENCE PERSISTS OR INCREASES, CONSULT A VETERINARIAN.

References

(1) Ritcher K.P., Ling G.V. Clinical response and urethal pressure profile changes after phenylpropanolamine in dogs with primary spincter incompetence, JAVMA, Vol. 187., No. 6, Sept. 15, 1985. 605-611.

Manufactured for: Vétoquinol USA Inc., 101 Lincoln Avenue, Buena, New Jersey 08310

1-800-267-5707

™Trademark of Vétoquinol S.A., Vétoquinol USA, Inc. Licensed User

Nac No.

10050352