P.G. 600 (Canada)This page contains information on P.G. 600 for veterinary use.
The information provided typically includes the following:
- P.G. 600 Indications
- Warnings and cautions for P.G. 600
- Direction and dosage information for P.G. 600
P.G. 600This treatment applies to the following species:
FOR VETERINARY USE ONLY
400 IU Equine Serum Gonadotrophin and 200 IU Chorionic Gonadotrophin for Injection
P.G. 600 is a combination of equine serum gonadotrophin (Pregnant Mare Serum Gonadotrophin or PMSG) and chorionic gonadotrophin (Human Chorionic Gonadotrophin or HCG) for use in prepuberal gilts that have not yet exhibited their first estrus and in sows at weaning. It is supplied as a freeze-dried powder with P.G. 600 Sterile Diluent for reconstitution.
5 mL of P.G. 600 contains:
Equine Serum gonadotrophin
P.G. 600 Indications
Prepuberal gilts: P.G. 600 is indicated for induction of fertile estrus (heat) in healthy prepuberal (non-cycling) gilts over five and one-half months of age and weighing at least 85 kg (185 lb.).
Sows at weaning: P.G. 600 is indicated for induction of estrus in healthy weaned sows experiencing delayed return to estrus.
NOTE: P.G. 600 IS INTENDED AS A MANAGEMENT TOOL TO IMPROVE REPRODUCTIVE EFFICIENCY IN SWINE PRODUCTION OPERATIONS. TO OBTAIN MAXIMUM BENEFIT FROM THIS PRODUCT, ESTRUS DETECTION AND OTHER ASPECTS OF REPRODUCTIVE MANAGEMENT MUST ALSO BE ADEQUATE. IF YOU ARE IN DOUBT ABOUT THE ADEQUACY OF YOUR BREEDING PROGRAM, CONSULT YOUR VETERINARIAN.
P.G. 600 Dosage And Administration
One 5 mL dose of reconstituted P.G. 600, containing 400 IU equine serum gonadotrophin and 200 IU chorionic gonadotrophin, should be injected subcutaneously into the gilt’s or sow’s neck behind the ear. Use as directed by a veterinarian.
Directions For Reconstituting The Product
Using a sterile syringe and a sterile hypodermic needle, transfer the contents of 1 vial of P.G. 600 Sterile Diluent into the P.G. 600 freeze dried powder. Shake the vial gently to dissolve the powder. Inject the reconstituted solution subcutaneously into the gilt’s or sow’s neck behind the ear. Use contents within 24 hours after reconstitution.
P.G. 600 Cautions
Treatment will not induce estrus in gilts that have already reached puberty (begun to cycle). Gilts that are less than five and one-half months of age or that weigh less than 85 kg (185 lb.) may not be mature enough to continue normal estrus cycles or maintain a normal pregnancy to full term after treatment. Treatment will not induce estrus in sows that are returning to estrus normally three to seven days after weaning. Delayed return to estrus often occurs during periods of adverse environmental conditions, and sows mated under such conditions may farrow smaller than normal litters.
Treated animals must not be slaughtered for use in food for at least 7 days after the latest treatment with this drug.
Keep out of reach of children.
In case of anaphylaxis administer 2 to 3 mL of epinephrine.
Gilts normally reach puberty (begin experiencing normal estrus cycles and exhibiting regular estrus or heat) at any time between six and eight months of age, although some gilts will not have exhibited their first estrus at ten months of age. Age at first estrus is influenced by several factors including breed type, season of the year, environmental conditions, and management practice.
Sows normally exhibit estrus three to seven days after weaning their litters; however, some otherwise healthy sows may not exhibit estrus for 30 days or more after weaning. The causes of delayed return to estrus in healthy sows are poorly understood, but probably include season of the year (so-called seasonal anestrus), adverse environmental conditions, such as high ambient temperatures and the number of previous litters, because the condition is more prevalent after the first litter than after later litters.
Clinical Pharmacology/mode Of Action
In gilts and sows, the action of serum gonadotrophin is similar to the action of Follicle-Stimulating Hormone (FSH), which is produced by the animals’ anterior pituitary gland. It stimulates the follicles of the ovaries to produce mature ova (eggs) and it promotes the outward signs of estrus (heat).
The action of chorionic gonadotrophin in gilts and sows is similar to the action of Luteinizing Hormone (LH), which is also produced by the animals’ anterior pituitary gland. It causes ovulation, and it promotes the formation of corpora lutea, which are necessary for the maintenance of pregnancy once the animals have become pregnant.
The combination of serum gonadotrophin and chorionic gonadotrophin in P.G. 600 induces fertile estrus in most prepuberal gilts and weaned sows three to seven days after administration. The animals may then be mated or, in the case of gilts, mating may be delayed until the second estrus after treatment.
Store between 2°-8°C. After reconstitution, the product may be stored between 2°-8°C for no longer than 24 hours. Unused solution should be disposed of properly and not stored for future use.
Five- 5 mL vials containing white freeze dried powder, and five- 5 mL vials containing sterile diluent.
Intervet Canada Corp., subsidiary of Merck & Co., Inc., Kirkland, Quebec, H9H 4M7
® Registered trademark of Intervet International B.V. Used under license.
14 September 2012
Intervet Canada Corp.
16750 ROUTE TRANSCANADIENNE, KIRKLAND, QC, H9H 4M7
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