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Newcastle Disease Vaccine (B1 Type, B1 Strain)

This page contains information on Newcastle Disease Vaccine (B1 Type, B1 Strain) for veterinary use.
The information provided typically includes the following:
  • Newcastle Disease Vaccine (B1 Type, B1 Strain) Indications
  • Warnings and cautions for Newcastle Disease Vaccine (B1 Type, B1 Strain)
  • Direction and dosage information for Newcastle Disease Vaccine (B1 Type, B1 Strain)

Newcastle Disease Vaccine (B1 Type, B1 Strain)

This treatment applies to the following species:
Manufacturer: Merial

Newcastle Disease Vaccine, B1 Type, B1 Strain, Live Virus

U.S. Vet. Lic. No.: 279

Active Ingredient(s): These vaccines contain the B1 strain of Newcastle disease virus. The virus has been propagated in fertile eggs from specific pathogen free flocks. The immunizing capability of these vaccines have been proven by the master seed immunogenicity test. These vaccines offer proven immunity with mild reactions.

Contains streptomycin and penicillin as bacteriostatic agents.

Contains fungizone as a fungistatic agent.

Notice: These vaccines have met the requirements of the USDA in regard to safety, purity, potency and the capacity to immunize normal, susceptible chickens. These vaccines have been tested by the master seed immunogenicity test for efficacy.

Newcastle Disease Vaccine (B1 Type, B1 Strain) Indications

These vaccines are recommended for the initial vaccination and revaccination of healthy chickens as an aid in the prevention of Newcastle disease.

The 5,000 dose size of the freeze-dried vaccine is recommended for the initial vaccination of healthy one day old chickens using the coarse spray application method, or for vaccination of healthy chickens 14 days of age or older using the drinking water application method or aerosol spray. Spray vaccination is recommended for revaccination only. Revaccination is recommended at four weeks and 16 weeks of age.

The 15,000 and 25,000 dose sizes of the freeze-dried vaccine are recommended for the primary vaccination or revaccination of 14-28 day old broiler type chickens using the drinking water or aerosol spray application. The 15,000 dose size is for the vaccination of healthy chickens 14 days of age or older.

These vaccines are recommended for the protection of healthy chickens which are free of all diseases. It is essential that the chickens be maintained under good environmental conditions and that exposure to disease viruses be reduced as much as possible in the field.

Dosage and Administration

A. Freeze-dried Vaccine (5,000 doses): For healthy chickens 14 days of age or older.

Directions for Coarse Spray Vaccination:

1. Be certain that all of the vaccinating equipment is clean before use. Never allow chemical disinfectants to come into contact with the vaccinating equipment.

2. Do not open and mix the vaccine until ready to vaccinate.

3. Remove the aluminum seal and rubber stopper from the vaccine vial.

4. Aseptically transfer a small amount (3-5 mL) of cool distilled water into the vaccine vial and gently mix.

5. Transfer the dissolved vaccine into cool, distilled water (5,000 doses in 350 mL) and gently mix.

6. Attach the spray head to the container and set the nozzle at a coarse spray setting.

7. To each tray of 100 birds, administer the vaccine by spraying 18-24 inches above tray.

8. Each tray of 100 birds should receive approximately 7 mL of vaccine. The exact amount can be determined by spraying into a calibrated tube to arrive at the number of applications needed to deliver 7 mL of vaccine.

9. Whatever volume of vaccine is used in the spray, take care to administer 5,000 doses to 5,000 birds.

10. Since coarse spray application is of a large droplet size, aerosol-like mist of the vaccine is reduced; however, always wear eye goggles and a face mask while spraying a live virus vaccine.

11. Any equipment used for the application of a live virus vaccine should not be used for any other purpose.

Directions for Drinking Water Vaccination:

1. Do not open or mix the vaccine until ready to vaccinate.

2. Remove all medication, sanitizers and disinfectants such as iodine from the drinking water 72 hours prior to vaccination.

3. Provide sufficient waterers so that all of the birds can drink at one time. Clean and rinse the waterers thoroughly.

4. Withhold all water from the birds for two (2) to four (4) hours prior to vaccination to stimulate thirst.

5. Add nonfat dry milk to the water at the rate of one (1) ounce per gallon before mixing the vaccine.

6. Remove the aluminum seal and rubber stopper from a vaccine vial.

7. Fill the vaccine vial two-thirds (2/3) full with clean, cool water and mix gently.

8. Mix the dissolved vaccine with water as shown below.

Age of birds

Water per 5,000 doses vaccine

2-4 weeks

12.5 gallons (45.5 L)

4-8 weeks

25 gallons (96 L)

8 weeks or older

50 gallons (189.5 L)

9. Distribute the vaccine solution among the waterers. Avoid direct sunlight.

10. Do not provide any other drinking water until all of the vaccine mixture has been consumed.

Spray Aerosol Vaccination: Use only for revaccination of healthy chickens two (2) weeks of age or older. Do not use for initial vaccination.

Use a sprayer delivering an aerosol-like mist to disperse the rehydrated vaccine quickly and evenly throughout a house of chickens.

1. Remove the aluminum seal and rubber stopper from the vaccine vial.

2. Fill the vaccine vial full with cool, distilled water. Pour the dissolved vaccine into a container and add approximately 500 mL of cool, distilled water per 5,000 doses of vaccine. Mix thoroughly.

3. For spray aerosol vaccination of a house of chickens, apply at the rate of 500 mL per 5,000 chickens.

4. Example: 20,000 birds will require 2,000 mL (approximately 2 quarts) of rehydrated vaccine.

5. Place the vaccine solution into the sprayer canister, set the discharge control to the coarsest setting and walk through the house spraying at the rate of 1,000 birds per minute. Direct the spray above the heads of the birds.

6. Whatever volume of vaccine solution is used, take care to administer 5,000 doses of vaccine to 5,000 birds.

7. Prior to spraying, reduce air flow to a minimum. Keep the air flow reduced for 20 minutes following spray vaccination.

8. Avoid direct contact with the vaccine solution. Wear goggles and a mask while spraying a live virus vaccine.

9. Any equipment used for the application of a live virus vaccine should not be used for any other purpose.

B. Freeze-dried Vaccine (15,000 doses): For healthy chickens 14 days of age or older.

Drinking Water Vaccination - Pouring Application:

1. Do not open or mix the vaccine until ready to vaccinate.

2. Remove all medications, sanitizers and disinfectants from the drinking water 72 hours (3 days) prior to vaccination.

3. Provide sufficient waterers so that all of the chickens can drink at one time. Shut off the water supply and allow the chickens to drink the troughs dry.

4. Raise the water troughs above the chickens' heads. Clean and rinse the waterers thoroughly.

5. Withhold all water from the chickens for a minimum of two (2) hours in warm weather to four (4) hours in cool weather prior to vaccination to stimulate thirst. The water withdrawal time should be reduced if half-house brooding is in process.

6. Calculate to supply the vaccine solution at a rate of three (3) gallons (11 L) per 1,000 chickens in cool weather and four (4) gallons (15 L) per 1,000 chickens in warm weather. The age of the chickens should be considered when calculating the water supply. Always use nonchlorinated water when vaccinating chickens.

Example:

10,000 chickens in cool weather x 3 gallons (11 L) = 30 gallons (114 L).

14,500 chickens in warm weather x 4 gallons (15 L) = 58 gallons (220 L).

7. Add one of the following to pouring water for vaccine distribution:

a. One (1) ounce (30 mL) of nonfat, dry milk per gallon (4 L) of water, or

b. Four (4) ounces (118 mL) of fresh skim milk per gallon (4 L) of water.

8. Prepare the vaccine concentrate as follows:

a. Prepare a container of milk/water figuring one (1) ounce (30 mL) of concentrate for one (1) gallon (4 L) of water to be used.

b. Add cool milk/water to the vial until the dried vaccine is dissolved. Add the vaccine to the container of milk/water to make the vaccine concentrate. Rinse the vaccine vial to remove all of the vaccine.

9. To make the vaccine solution, add one (1) ounce (30 mL) of concentrate for each gallon (4L) of water needed.

10. Distribute the vaccine solution among the waterers. Avoid direct sunlight.

11. Lower the water troughs and allow the birds to drink freely. Add the remaining vaccine solution to the troughs as the birds drink.

12. Do not provide any additional drinking water until all of the vaccine solution is consumed.

Drinking Water Vaccination - Proportioner Application: Several types of medicator/proportioners are commercially available. Set the proportioner to deliver one (1) ounce (30 mL) of vaccine concentrate per one (1) gallon (4 L) of water.

1. Do not open or mix the vaccine until ready to vaccinate.

2. Remove all medications, sanitizers and disinfectants from the proportioner 72 hours (3 days) prior to vaccination.

3. Clean all containers, hoses, and waterers prior to vaccination.

4. Withhold all water from the chickens for a minimum of two (2) hours in warm weather to four (4) hours in cool weather prior to vaccination to stimulate thirst.

5. Calculate to supply the vaccine solution at a rate of three (3) gallons (11 L) per 1,000 chickens in cool weather and four (4) gallons (15 L) per 1,000 chickens in warm weather. The age of the chickens should be considered when calculating the water supply. Always use nonchlorinated water when vaccinating chickens.

Example:

10,000 chickens in cool weather x 3 gallons (11 L) = 30 gallons (114 L).

14,500 chickens in warm weather x 4 gallons (15 L) = 58 gallons (220 L).

6. Prepare the vaccine concentrate as follows:

a. Add three (3) ounces (90 mL) of nonfat, dry milk per 16 ounces (473 mL) of cool water, or

b. Use undiluted, cool, fresh skim milk.

7. To make the vaccine solution, add one (1) ounce (30 mL) of concentrate for each gallon (4 L) of water needed.

8. Add the milk solution to the vial until the dried vaccine is dissolved. Rinse the vaccine vial to remove all of the vaccine.

9. Insert the proportioner hose into the vaccine concentrate and start the water flow. Continue until all of the concentrate has been consumed before changing the water supply to direct flow.

10. Do not medicate or use disinfectants for 24 hours after vaccination.

Coarse Spray Application: For use in houses containing between 10,000 and 15,000 chickens. Coarse spray application is recommended for revaccination only and not as a primary vaccination. Use a sprayer delivering a coarse spray pattern to dispense the rehydrated vaccine quickly and evenly throughout a house of chickens.

1. Prior to spraying, reduce the air flow by raising curtains or stopping fans. Air movement should be limited for 15 minutes following vaccination.

2. Fill the vaccine container with cool, distilled, de-ionized water.

3. Pour the reconstituted vaccine into a clean container and add five (5) ounces (150 mL) of cool water for each 1,000 chickens to be vaccinated.

4. Place the vaccine solution into the spray canister and walk through the house spraying at the rate of 1,000 chickens per minute. Direct the spray directly above the heads of the chickens.

5. Avoid direct contact with the vaccine solution. Wear goggles and a mask while spraying.

6. Do not use vaccinating equipment for any other purposes.

C. Freeze-dried Vaccine (25,000 doses): For 14-28 day old broiler type chickens.

Directions of Drinking Water Vaccination: For use in houses containing between 15,000 and 25,000 chickens. Do not use the drinking water vaccination method for chickens under 14 days of age.

Drinking Water - Pouring Application:

1. Do not open or mix the vaccine until ready to pour the vaccine solution into the water troughs.

2. Stop use of medication, sanitizers and disinfectants such as iodine from the drinking water 72 hours (3 days) prior to vaccination.

3. Shut off the water supply and allow the chickens to drink the troughs dry. Water should be withheld from chickens for a minimum of two (2) hours in warm weather to four (4) hours in cold weather. The water withdrawal times should be reduced if half-house brooding is in process.

4. Rinse the water troughs above the chickens heads. Clean and rinse the waterers thoroughly.

5. Calculate to supply the vaccine solution at a rate of three (3) gallons per 1,000 chickens in cold weather and four (4) gallons per 1,000 chickens in warm weather.

Example:

17,000 chickens in cool weather x 3 gallons = 51 gallons.

22,500 chickens in warm weather x 4 gallons = 90 gallons.

6. Add one of the following to pouring water for vaccine distribution:

a. One (1) ounce of nonfat dry milk per gallon of water, or

b. Four (4) ounces of fresh skim milk per gallon of water.

Milk or milk solids are added to neutralize low levels of virucidal chemicals which may be present in farm water.

7. Prepare the vaccine concentrate as follows:

a. Prepare a container of milk/water figuring one (1) ounce of concentrate for one (1) gallon of water to be used.

b. Open the vaccine container by removing the aluminum seal and stopper.

c. Add cool milk/water to the vial until the dried vaccine is dissolved. Add the vaccine to the container of milk/water to make the vaccine concentrate. Rinse the vaccine bottle to remove all of the vaccine.

8. To make the vaccine solution, add one (1) ounce of concentrate for each gallon of pouring water needed. Mix well.

9. Fill all of the water troughs full with the vaccine solution. Avoid direct sunlight.

10. Lower the water troughs and allow the birds to drink freely. Add the remaining vaccine solution to the troughs as the birds drink.

11. Do not provide any additional drinking water until all of the vaccine solution has been consumed.

Drinking Water - Proportioner Application: Several types of medicator/proportioners are commercially available such as the dosmatic liquid dispenser. Set the proportioner to deliver one (1) ounce of vaccine concentrate per one (1) gallon of water.

1. Stop use of medication, sanitizers and disinfectants such as iodine from dispenser 72 hours (3 days) prior to vaccination. Clean all containers and hoses prior to vaccination. Do not use medicator containers for vaccine use.

2. Shut off the water supply for four (4) hours in cool weather and two (2) hours in warm weather before vaccination to stimulate thirst.

3. Calculate three (3) gallons of vaccine solution per 1,000 birds in cool weather and four (4) gallons in warm weather.

4. Calculate one (1) ounce of vaccine concentrate per gallon of water to make vaccine solution for bird consumption.

5. Vaccine concentrate preparation:

a. Add three (3) ounces of dried nonfat milk per 16 ounces of cool water, or

b. Use undiluted, cool, fresh skim milk.

6. Open the vaccine container by removing the aluminum seal and stopper.

7. Add the milk solution to the bottle, mix well, and add to the vaccine concentrate container. Rinse the vaccine bottle to remove all of the vaccine. Mix well.

8. Insert the dosmatic hose into the vaccine concentrate and start the water flow. Continue until all of the concentrate has been consumed before changing the water supply to direct flow.

9. Do not medicate or use disinfectants for 24 hours after vaccination.

Spray Application: For use in houses containing between 15,000 and 25,000 chickens. Spray application is recommended only for revaccination and not as a primary vaccination.

Coarse Aerosol Application: Use a sprayer delivering a coarse aerosol mist to dispense the rehydrated vaccine quickly and evenly throughout a house of chickens.

Directions:

1. Prior to spraying, reduce the air flow by raising curtains or stopping fans. Air movement should be limited for 15 minutes following vaccination.

2. Remove the aluminum seal and rubber stopper. Fill the vaccine container with cool water.

3. Pour the reconstituted vaccine into a clean container and add 150 mL (5 oz.) of cool water for each 1,000 chickens to be vaccinated.

4. Place the vaccine solution into the spray canister and walk through the house spraying at the rate of 1,000 birds per minute. Direct the spray directly above the heads of the chickens.

5. Use all of the vaccine solution for each house containing 15,000 to 25,000 birds.

6. Avoid direct contact with the vaccine solution. Wear goggles and a mask while spraying.

7. Do not use vaccinating equipment for other purposes.

Precaution(s): Storage Conditions: Store freeze-dried vaccine at 35-45°F (2-7°C). Do not freeze.

Caution(s): Do not vaccinate diseased birds or birds exhibiting respiratory distress and parasite infestations.

Vaccinate all birds on the same premises at the same time.

Administer a minimum of one dose for each bird.

Avoid stress conditions during and following vaccination.

Do not place chickens in contaminated premises.

Exposure to disease must be minimized as much as possible.

For veterinary use only.

Do not start vaccination program for replacement pullets after birds are 16 weeks old.

Use the entire contents when first opened.

Burn this container and all unused contents.

Since Newcastle disease virus can cause inflammation of the eyelids of humans lasting up to three days, care should be taken to avoid contamination of eyes, hands and clothing with this vaccine.

The capability of these vaccines to produce satisfactory results depends upon many factors, including, but not limited to, conditions of storage and handling by the user, administration of the vaccine, health and responsiveness of individual animals and degree of field exposure. Therefore, directions for use should be followed carefully.

The use of these vaccines is subject to applicable state and federal laws and regulations.

Warning(s): Do not vaccinate within 21 days before slaughter.

Presentation: Freeze-dried vaccine: 25 x 5,000 and 15 x 25,000 dose vials.

NAC No.: 1105031.4

MERIAL, INC. (POULTRY BIOLOGICS)
3239 SATELLITE BLVD., DULUTH, GA, 30096
Telephone:   888-637-4251
Website:   www.merial.us
Every effort has been made to ensure the accuracy of the Newcastle Disease Vaccine (B1 Type, B1 Strain) information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2016 North American Compendiums. Updated: 2016-10-31

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