Metacam for Swine (Canada)

Company: Boehringer

Meloxicam 5 mg/mL solution for injection

Sterile

Veterinary Use Only

DIN 02452448

Active Ingredient

Meloxicam 5 mg/mL

Preservative: Ethanol 150 mg/mL

Therapeutic Classification: Nonsteroidal anti-inflammatory drug (NSAID).

Metacam for Swine Indications

For the relief of post-operative pain associated with minor soft tissue surgery such as castration.

Dosage and Administration

Single intramuscular injection at a dosage of 0.4 mg meloxicam/kg body weight (0.1 mL/1.25 kg). The product should be administered 30 minutes prior to painful procedure.

Contraindications

Do not use in animals suffering from gastrointestinal disorders such as irritation and hemorrhage, impaired hepatic, cardiac or renal function and hemorrhagic disorders or where there is individual hypersensitivity to the product.

Do not administer concurrently with steroidal, other nonsteroidal anti-inflammatory drugs or with anticoagulant agents.

Concomitant use of NSAIDs with aminoglycoside antimicrobials in very young animals may result in renal toxicity.

Cautions: Avoid use in very severely dehydrated, hypovolaemic or hypotensive animals which require parenteral rehydration, as there may be a potential risk of increased renal toxicity.

Use of anti-inflammatories in very young or debilitated animals may involve additional risk.

Safety in piglets less than 4 days of age has not been demonstrated.

Warnings

Treated swine must not be slaughtered for use in food for at least 5 days after the latest treatment with this drug. Keep out of reach of children.

Adverse Reactions

In very rare cases, anaphylactoid reactions may occur and should be treated symptomatically.

In very rare cases, anaphylactoid reactions may occur and should be treated symptomatically.

Pharmacology

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class which acts by inhibition of prostaglandin synthesis, thereby exerting anti-inflammatory, analgesic and antipyretic properties. Meloxicam also has anti-endotoxic properties because it has been shown to inhibit production of thromboxane B2 induced by E. coli endotoxin administration in calves.

Toxicology: The acute oral toxicity (LD₅₀) of meloxicam assessed in rats, mini-pigs, mice and rabbits was >80 mg/kg, 1600 mg/kg, 470 mg/kg and 320 mg/kg, respectively. Repeated dose toxicity studies in rats, mice and mini-pigs demonstrated that the primary target organs for toxicity were the gastrointestinal tract (pyloric, duodenal and small intestine ulceration) and kidneys (scarring, necrosis and pyelonephritis).

Storage

Store at or below 25°C. Keep from freezing. Upon opening, use within 28 days.

Metacam^® is a registered trademark of Boehringer Ingelheim Vetmedica GmbH, used under license.

Boehringer Ingelheim (Canada) Ltd., 5180 South Service Road, Burlington, Ontario L7L 5H4

Revised: 02-2016

70765/001

Presentation: 12 x 20 mL carton.

CPN: 1230148.0