M-Ninevax-C
This treatment applies to the following species:PASTEURELLA MULTOCIDA VACCINE
Avirulent Live Culture, Avian Isolate
DIRECTIONS FOR USE, READ CAREFULLY
Description
This vaccine is a live bacterial vaccine containing the mild avirulent M-9 strain of Pasteurella multocida, Heddleston Type 3‑4 cross, in a freeze-dried preparation sealed under vacuum. The seed culture used to make this vaccine has been laboratory tested for protection in chickens against challenge with the X-73 (Type-1) strain of P. multocida and in turkeys against challenge with the P1059 (Type 3) strain of P. multocida.
M-Ninevax-C Indications For Use
This product has been shown to be effective for the vaccination of healthy chickens 10-12 weeks of age against pasteurellosis (fowl cholera) due to Pasteurella multocida Type 1 infection and healthy turkeys 6 weeks of age or older against pasteurellosis (fowl cholera) due to Pasteurella multocida Type 3 infection. Duration of immunity has not been established. For more information regarding efficacy and safety data, see productdata.aphis.usda.gov.
When To Vaccinate
BY WING-WEB:
Chickens: Use by wing-web stab to vaccinate chickens 10-12 weeks of age and again at 18-20 weeks. There should be at least 6 weeks and not more than 10 weeks between vaccinations. Initial vaccination in chickens over 12 weeks of age may be undesirable because larger granulomas may develop at the site of inoculation and this may result in downgrading of carcasses at slaughter.
Turkeys: Use by wing-web stab to vaccinate turkey breeders 15 weeks of age or older. Birds should initially be wing-web vaccinated at 15-18 weeks of age and again 8 weeks later. Turkey breeders must be vaccinated at least twice with live fowl cholera vaccine via oral route prior to wing-web vaccination. Use of this vaccine in turkeys which have not been orally prevaccinated may cause severe postvaccination reactions, including lameness and death. The interval between the last oral vaccination and the first wing-web vaccination should not exceed 6 weeks. Additional wing-web vaccination every 6-8 weeks throughout the life of the bird may be required in areas of endemic exposure to fowl cholera.
BY DRINKING WATER:
Turkeys: Best results are obtained when vaccine is administered initially to turkeys 6 to 8 weeks of age, followed by a booster dose three weeks later, and repeated every 4 to 6 weeks thereafter as necessary according to exposure conditions. Initial vaccination with this vaccine should not be conducted in turkeys older than 12 weeks of age. Do not use this vaccine within 2 weeks before or 2 weeks after vaccinating turkeys with live virus Newcastle vaccine.
Vaccination Programs
Many factors must be considered in determining the proper vaccination program for a particular farm or poultry operation. To be fully effective, the vaccine must be administered to healthy receptive birds held in a proper environment under good management. In addition, the response may be modified by the age of the chickens and their immune status. Seldom does one vaccination under field conditions produce complete protection for all individuals, in a given flock. The amount of protection required will vary with the type of operation and the degree of exposure that a flock is likely to encounter. For these reasons a program of periodic revaccination may be required.
Preparation Of Vaccine
FOR WING-WEB ADMINISTRATION
DO NOT OPEN AND MIX THE VACCINE UNTIL READY TO BEGIN VACCINATION. USE VACCINE IMMEDIATELY AFTER MIXING.
1. Remove the tear-off seal and stopper from the vaccine vial.
2. Remove the seal and stopper from the vial containing the diluent.
3. Hold the diluent bottle firmly in an upright position and insert the shorter end of the transfer tube. Still holding the diluent bottle in an upright position, insert the neck of the vaccine vial over the longer end of the transfer tube. The vaccine vial should snap into position, connecting the two vials securely.
4. Invert the two containers so that the vaccine vial is on the bottom and allow the diluent to flow into the vaccine vial. If the diluent does not flow freely, squeeze the diluent bottle gently and the diluent will flow into the vaccine vial. The vaccine vial should be completely filled with diluent to prevent excess foaming.
5. Hold the joined containers by the ends; shake vigorously until the vaccine plug is completely dissolved.
6. Return the joined containers to their original position (diluent bottle on the bottom). Allow the vaccine to flow into the diluent bottle. If the vaccine does not flow into the diluent bottle, tap or squeeze the diluent bottle gently and release to draw the vaccine into the diluent bottle. Be sure all the product is removed from the vaccine vial.
7. Remove the vaccine vial and transfer tube from the neck of the diluent bottle.
8. The vaccine is now ready to use.
9. Wash hands thoroughly after mixing the vaccine.
Wing-web Administration
FOR CHICKENS 10-12 WEEKS OF AGE AND TURKEYS 15 WEEKS OF AGE OR OLDER
1. Vaccination is accomplished by dipping the needle applicator into the mixed vaccine and piercing the webbed portion of the underside of the wing. Avoid piercing through feathers which may wipe off the vaccine and avoid hitting the wing muscle or bone to minimize reaction. The applicator is designed to pick up the proper amount of vaccine on the needles, which is deposited in the tissues when the wing is pierced.
2. Redip the applicator in the vaccine before each application. Excess vaccine adhering to the applicator should be removed by touching the applicator to the inside of the vial.
3. At 5 to 10 days following vaccination, a swelling of the skin (subcutaneous granuloma) will develop on the wing-web at the point of inoculation. The absence of this local reaction may mean that improper vaccination methods were used. Examination for these “takes” at 7 days post-vaccination may be used to assure that proper vaccination has been conducted.
Preparation Of Vaccine
FOR DRINKING WATER
DO NOT OPEN AND MIX THE VACCINE UNTIL READY TO BEGIN VACCINATION. USE VACCINE IMMEDIATELY AFTER MIXING.
1. Remove the tear-off seal and stopper from the vial containing the lyophilized vaccine.
2. Carefully pour clean, cool, non-chlorinated water into the vaccine vial until the vial is approximately two-thirds full.
3. Insert the rubber stopper and shake vigorously until all material is dissolved.
4. The vaccine is now ready to be applied as per label in accordance with the directions below. For best results, be sure to follow directions carefully!
Drinking Water Administration
FOR TURKEYS 6 TO 8 WEEKS OF AGE
1. Do not use any disinfectants in the drinking water for 48 hours before vaccinating and 24 hours after vaccination.
2. Withhold water from the turkeys until they are thirsty.
3. Calculate the water volume needed so the vaccine will be consumed in approximately 2 hours.
4. Optional: as an aid in preserving the virus, add a vaccine stabilizer to the stock solution or to the tank containing clean, cool, non-chlorinated water. Agitate thoroughly. Follow the manufacturer’s rate of administrations and wait time.
5. Add rehydrated vaccine from vial to the water and mix thoroughly.
6. Turn on tank valve or automatic dosing system.
7. Provide as sole source of drinking water until all vaccine-water solution has been consumed.
M-Ninevax-C Caution
1. VACCINATE ONLY HEALTHY BIRDS.
2. All birds should be vaccinated at the same time.
3. Do not medicate birds with antibacterial drugs 3 days prior to or 5 days after vaccination.
4. Use entire contents when first opened.
5. Do not vaccinate within 21 days before slaughter.
6. Store vaccine at 2° to 8° C (35° to 46° F).
7. Inactivate unused contents before disposal.
8. Do not mix with other products, except as specified on the label.
9. In case of human exposure, contact a physician.
10. FOR ANIMAL USE ONLY.
Notice
This vaccine has undergone rigid potency, safety and purity tests, and meets Merck Animal Health, U.S. and local regulatory requirements. It is designed to stimulate effective immunity when used as directed, but the user must be advised that the response to the product depends upon many factors, including, but not limited to, conditions of storage and handling by the user, administration of the vaccine, health and responsiveness of the individual birds and the degree of field exposure. Therefore, directions should be followed carefully.
Records
Keep a record of vaccine, quantity, serial number, expiration date, and place of purchase; the date and time of vaccination; the number, age, breed, and locations of birds; names of operators performing the vaccination and any observed reactions.
FEDERAL REGULATIONS PROHIBIT THE REPACKAGING OR SALE OF THE CONTENTS OF THIS CARTON IN FRACTIONAL UNITS. DO NOT ACCEPT IF SEAL IS BROKEN.
Intervet Inc. d/b/a Merck Animal Health, Omaha, NE 68103 USA
VLN 165A/PCN 1871.03
1 800 211-3573 (USA)
1 866 683-7838 (CAN)
For patent information:
http://www.merck.com/product/patent/home.html
359257 R3
|
Code |
|
10 x 1,000 Doses |
148288 |
376528 R2 398791 R1 |
CPN: 1047125.5
Intervet Inc.
126 E. LINCOLN AVENUE, PO BOX 2000, Rahway, NJ, 07065
Customer Service: | 800-521-5767 | |
Technical Service (Companion Animal): | 800-224-5318 | |
Technical Service (Livestock): | 800-211-3573 | |
Website: | www.merck-animal-health-usa.com |
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