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Immunocidin Equine

This page contains information on Immunocidin Equine for veterinary use.
The information provided typically includes the following:
  • Immunocidin Equine Indications
  • Warnings and cautions for Immunocidin Equine
  • Direction and dosage information for Immunocidin Equine

Immunocidin Equine

This treatment applies to the following species:
Company: NovaVive USA


For Veterinary Use Only

Description and Action: The Mycobacteriaceae have been known for many years to have antitumor activity. Immunocidin® Equine is an emulsion of mycobacterial cell wall fractions that have been modified to reduce their toxic and allergic effects, but retain their antitumor activity. Immunocidin® Equine stimulates the activation of macrophages and thymic lymphocytes which kill tumor cells.

Indications: Immunocidin® Equine is recommended for the immunotherapy of sarcoid tumors in horses. Although Immunocidin® Equine is administered by intratumoral injection, the response is generalized, and untreated sites frequently undergo regression. Remissions cannot be guaranteed as each tumor will vary in its response.

Adverse Reactions

Mild fever, drowsiness, and an increased metabolic rate leading to decreased appetite may occur for one to two days following an Immunocidin® Equine injection. Local inflammation which is sensitive to the touch occurs fairly often but it usually is not bothersome to the patient. Necrosis with suppuration may occur in regressing tumors and clients should be informed that the tumor may drain for several weeks. Tumors may be aspirated with a sterile syringe and needle to help prevent drainage. If inconvenient drainage develops, it can often be stopped by the application of astringents such as silver nitrate or styptic powders.


Immunotherapy may not be as effective in animals receiving concurrent immunosuppressive therapies. Avoid the use of corticosteroids or ACTH where possible.

Immunocidin Equine Caution

The inflammatory response with edema and malaise occasionally is severe after the initial treatment. Therapy should be discontinued until the reaction has subsided. Animals with a history of hyper-immune disease (vaccine bumps, allergies, etc.) should be closely monitored. In the event of urticaria, lymphadenitis, cellulitis, or abscessation, treat appropriately. Discontinue Immunocidin® Equine therapy in animals which develop these signs.

Administration and Dosage: Immunocidin® Equine is administered only by intratumoral injection. The entire tumor and a small region of adjacent and underlying tissue must be thoroughly infiltrated using no larger than a 20-gauge needle. Injection without careful infiltration of the tumor may not be effective. It is important to make sure that the emulsion is thoroughly mixed prior to injection. The sarcoid tissue may be very firm and extra pressure on the syringe plunger may be required to infiltrate the tumor. The injection may produce pain in some animals; local analgesics or NSAIDs may be used without decreasing the immunotherapeutic effect. Dosage varies with tumor size, but 1 mL should be considered a minimum dose.

Equine sarcoids are very responsive to immunotherapy with Immunocidin® Equine. Large, pedunculated sarcoids should be debulked by partial excision prior to therapy. Immunocidin® Equine is safe for use in pregnant mares. Treatment should be repeated every 1 to 3 weeks. Tumors that fail to respond after 4 treatments should be considered refractory and therapy discontinued. Ninety-four percent of horses treated were free of tumor two years later. Individual doses range from 1 to 60 mL and average about 5 to 10 mL. The average cumulative dose is about 30 mL.

Precaution: Store at 36-45°F (2-7°C) in a refrigerator but do not freeze. The emulsion may separate on standing. Resuspend by shaking or rotating the vial between the hands until the emulsion has a homogeneous “milky” appearance. Use entire contents when first opened. This product contains gentamicin as a preservative. Do not administer within 21 days of slaughter. KEEP OUT OF REACH OF CHILDREN.

Packaging: Contains 1 x 5 mL vial

Manufactured by NovaVive USA Inc., 119 Rowe Rd., Athens, Georgia 30601

U.S. Vet. Lic. No. 289

TOLL FREE: 1-844-663-3349


Protected by one or more of the following patents:

US: 4744984, 5632995, 5759554, 6139844, 6890541

CA: 1293190, 2154689, 2170142, 2284932, 2284937, 2378888

CPN: 1843004.0

119 ROWE RD., ATHENS, GA, 30601
Toll-Free:   1-844-663-3349
Every effort has been made to ensure the accuracy of the Immunocidin Equine information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2021 Animalytix LLC. Updated: 2020-12-31