E-Se Injectable (Canada)This page contains information on E-Se Injectable for veterinary use.
The information provided typically includes the following:
- E-Se Injectable Indications
- Warnings and cautions for E-Se Injectable
- Direction and dosage information for E-Se Injectable
E-Se InjectableThis treatment applies to the following species:
VETERINARY USE ONLY
E-SE is an emulsion of selenium-tocopherol for the prevention and treatment of myositis (Selenium-Tocopherol Deficiency) syndrome in horses. Each mL contains: Active ingredients: Selenium (as sodium selenite) 2.5 mg, Vitamin E (as d-alpha tocopheryl acetate) 68 IU; Preservative: benzyl alcohol 0.02 mL (2% v/v); Inactive ingredients: polyoxyethylated vegetable oil 250 mg, water for injection q.s. Sodium hydroxide or hydrochloric acid may be added to adjust pH.
It has been demonstrated that selenium and tocopherol exert physiological effects and that these effects are intertwined with sulfur metabolism. Additionally, tocopherol appears to have a significant role in the oxidation process, thus suggesting an interrelationship between selenium and tocopherol in overcoming sulfur-induced depletion and restoring normal metabolism. Although oral ingestion of adequate amounts of selenium and tocopherol would seemingly restore normal metabolism, it is apparent that the presence of sulfur and, perhaps, other factors interfere with the proper utilization of selenium and tocopherol during the digestive process. When selenium and tocopherol are injected, they bypass the digestive process and exert their full metabolic effects promptly on cell metabolism.
E-Se Injectable Indications
Horses: E-SE is recommended for the control of the following clinical signs when associated with myositis (Selenium-Tocopherol Deficiency) syndrome: rapid respiration, profuse sweating, muscle spasms and stiffness, elevated SGOT.
This drug is not to be administered to horses that are to be slaughtered for use in food.
Selenium is toxic if administered in excess. A fixed dose schedule is therefore important (read package insert for each selenium-tocopherol product carefully before using). Emulsions injected intramuscularly into the horse may produce transitory local muscle soreness and can be prevented to some degree by injecting deeply (5 to 6 cm - 2 to 2 1/2 inches), in divided doses, in two or more sites. Do not continue therapy in horses demonstrating such sensitivity.
Anaphylactoid reactions, some of which have been fatal, have been reported in horses administered with E-SE injectable. Signs include excitement, sweating, trembling, ataxia, respiratory distress, and cardiac dysfunction. Discontinue injection immediately on early signs of anaphylactoid reaction.
E-Se Injectable Cautions
Selenium-Tocopherol Deficiency (STD) syndrome produces a variety and complexity of symptoms often interfering with a proper diagnosis. Even in selenium deficient areas there are other disease conditions which produce similar clinical signs. It is imperative that all these conditions be carefully considered prior to treatment of STD syndrome. Serum selenium levels, elevated SGOT and creatinine levels may serve as aids in arriving at a diagnosis of STD, when associated with other indices.
Important: Use only the selenium-tocopherol product recommended for each species. Each formulation is designed for the species indicated to produce maximum efficacy and safety.
E-Se Injectable Dosage And Administration
Deep intramuscular injections, in divided doses, in two or more sites in the gluteal or cervical muscles. Dosage: 1 mL per 45 kg of body weight. May be repeated at 5-10 day intervals.
100 mL sterile, multiple dose, glass vials. Product Code: 280100
Store between 2°C and 25°C. Protect from freezing.
Intervet Canada Corp., Kirkland (Quebec), H9H 4M7
® Registered trademark of Schering Corporation, used under license by Intervet Canada Corp.
CND 3485 1 V
Intervet Canada Corp.
16750 ROUTE TRANSCANADIENNE, KIRKLAND, QC, H9H 4M7
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