Skip to main content

Denestra S-Adenosylmethionine (SAMe) 400 mg

This treatment applies to the following species:
Company: PHS

Veterinarian Recommended

For Large Dogs


● Liver

● Joints

● Cognitive Function

Product Facts

Active Ingredients

per (Tablet):

S-Adenosylmethionine (SAMe) tosylate disulfate

400 mg

Inactive Ingredients

Cellulose, Citric Acid, Mannitol, Modified Cellulose Gum, Silica, Sodium Starch Glycolate, Stearic Acid. (Coating Ingredients: Hydroxypropyl Methylcellulose Phthalate or Hydroxypropyl Methylcellulose and Methacrylic Acid Copolymer, Titanium Dioxide, Triacetin and Yellow Ochre.)

Cautions: Safe use in pregnant animals or animals intended for breeding has not been proven. If animal’s condition worsens or does not improve, stop product administration and consult your veterinarian. Caution in use with antidepressants.

For use in dogs only. Denestra® with SAMe supports liver metabolic activity and proper liver function in dogs. SAMe, or S-Adenosyl-Methionine, is a naturally occurring substance found in all living beings. SAMe in its biological form contributes to better pet health through a number of chemical processes: transmethylation, trassulfuration, and aminopropylation. These processes can affect liver and joint health in animals. Through the process of transsulfuration, natural SAMe is converted into a compound called glutathione, a potent antioxidant and liver detoxification tool. This detoxification tool assists normal cleansing of the liver from impurities, which in turn may help the body from exposure to heavy metal or environmental toxins.

Directions For Use

Denestra should be administered on an empty stomach, one hour before or two hours after a meal (overnight fast is preferred). Do not cut or crush tablets. May be disguised in treats for easier administration. Dosage may be increased or decreased at any time at the recommendation of your Veterinarian.

Size of Dog


35 - 65 lb

1 Tablet

66 - 100 lb

2 Tablets

Over 100 lb

3 Tablets


For animal use only. Keep out of the reach of children and animals. In case of accidental overdose, contact a health professional immediately.

Store in a cool dry place. Keep container at room temperature (59°F-86°F). Keep tablets in their original blister pack until used. Tablets are sensitive to moisture and extreme heat.

Manufactured for:


34501 Seventh St. Union City, CA 94587

1 (877) 564-6862



Net Contents:



60 Tablets

2.4 oz (67 g)
(Stabilized Enteric Coated Tablets in Blister Packs)



CPN: 6210058.1

34501 7TH ST., UNION CITY, CA, 94587
Toll-Free:   877-564-6862
THIS SERVICE AND DATA ARE PROVIDED "AS IS". DVMetrics assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the DVMetrics service and data. See the Terms of Use for further details.


Copyright © 2024 Animalytix LLC. Updated: 2024-02-27