Skip to main content

Denagard Medicated Premix (Canada)

This page contains information on Denagard Medicated Premix for veterinary use.
The information provided typically includes the following:
  • Denagard Medicated Premix Indications
  • Warnings and cautions for Denagard Medicated Premix
  • Direction and dosage information for Denagard Medicated Premix

Denagard Medicated Premix

This treatment applies to the following species:
Company: Elanco

(tiamulin hydrogen fumarate)

Medicated Premix

DIN 00860735

Veterinary Use Only

For Use in Swine Feed Only

Active Ingredient

Tiamulin Base: 17.8 g/Kg (equivalent to 22 g tiamulin hydrogen fumarate/kg)


Denagard Premix contains 14-desoxy-I 4-[(2- diethylaminoethyl) mercaptoacetoxy] mutilin hydrogen fumarate, a semi-synthetic derivative of the antibiotic, pleuromutilin. Each kg contains 17.8 g of tiamulin base equivalent to 22 g of tiamulin hydrogen fumarate.

Therapeutic Classification: Antibiotic

Denagard Medicated Premix Indications

For use in swine for the treatment and for the prevention of swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae susceptible to tiamulin.

Dosage and Administration

To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Mixing Directions: Thoroughly mix Denagard Premix into complete nonmedicated swine feed for the treatment or for the prevention of swine dysentery at the rates per metric tonne (1,000 kg) of feed as shown in the table below.

Denagard Medicated Premix Indications

Tiamulin Base Use Level

Amount of Denagard Premix per tonne of Feed

Treatment of Swine Dysentery

178.1 g/tonne (1,000 kg)

10.0 kg/tonne (1,000 kg)

Prevention of Swine Dysentery

31.2 g/tonne (1,000 kg)

1.75 kg/tonne (1,000 kg)

Feeding Directions: For treatment of swine dysentery, feed at 178.1 g/tonne for 14 days.

For prevention of swine dysentery, feed continuously at 31.2 g/tonne as the sole ration to swine on premises with a history of swine dysentery but where signs of the disease have not yet occurred. Feed continuously at 31.2 g/tonne to prevent reinfection following use of tiamulin at 178.1 g/tonne for 14 days or following use of tiamulin medicated water for treatment of swine dysentery associated with Brachyspira hyodysenteriae susceptible to tiamulin.

Note: Use as the only source of tiamulin. During treatment swine should be housed under conditions of adequate space and sanitation.


1. Do not use in feed containing pellet binding agents.

2. Do not feed to animals other than swine.

3. Do not use undiluted.

4. Swine being medicated with Denagard Premix should not have access to or be treated with tiamulin incompatible polyether ionophores (e.g., monensin, lasalocid, narasin, salinomycin and semduramicin).

Cautions: For use in swine feed only. This drug should not be administered to sows and gilts 4 weeks after service.


Treated animals must not be slaughtered for use in food for at least 7 days after the latest treatment with this drug at 178.1 g/tonne or for at least 2 days after the latest treatment with this drug at 31.2 g/tonne.

Avoid contact with the skin. Direct contact with the skin or mucous membranes may cause irritation. If contact occurs, wash with soap and water. KEEP OUT OF REACH OF CHILDREN.

Adverse Reactions

1. Overdoses of tiamulin have sometimes produced transitory salivation, vomiting and an apparent calming effect on the pig. In very rare cases, death has been reported.

2. In rare cases, redness of the skin, primarily over the ham and underline, has been observed during medication.

3. If signs of toxicity or redness of the skin occurs, promptly discontinue use of the therapeutic level of medicated feed.


Store at less than 25 °C in a dry place.

Presentation: Denagard Premix is supplied in a 15 kg bag containing 17.8 g of tiamulin per kg (equivalent to 22 g of tiamulin hydrogen fumarate/kg).

Date: July 2017

Manufactured and Distributed by: Elanco Canada Limited, 150 Research Lane, Suite 120, Guelph, Ontario N1G 4T2


Denagard, Elanco and the diagonal bar logo are trademarks of Eli Lilly and Company or its affiliates.

Net Weight:


15 kg


CPN: 1231085.4

Customer Service:   800-265-5475
Fax:   519-821-7831
This service and data are provided "AS IS". DVMetrics and assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the DVMetrics and services and data. See the terms of use for further details.

Copyright © 2022 Animalytix LLC. Updated: 2021-12-02