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Coliprotec F4 (Canada)

This page contains information on Coliprotec F4 for veterinary use.
The information provided typically includes the following:
  • Coliprotec F4 Indications
  • Warnings and cautions for Coliprotec F4
  • Direction and dosage information for Coliprotec F4

Coliprotec F4

This treatment applies to the following species:
Manufacturer: Prevtec microbia

Lyophilized

Escherichia coli Vaccine

Avirulent Live Culture, Porcine Isolate

FOR ORAL USE ONLY IN SWINE

Description Of The Vaccine

Coliprotec® F4 is an oral live vaccine, containing naturally avirulent Escherichia coli bacteria, recommended for the vaccination of healthy weaned pigs, 17 days of age or older, as an aid in the prevention of post-weaning diarrhea (PWD) caused by F4(K88)-positive Escherichia coli. Clinical studies confirmed that the Coliprotec® F4 vaccine significantly reduced intestinal colonization of virulent enterotoxigenic Escherichia coli (ETEC), diarrhea, and accumulation of fluid in the intestines after a challenge.

Precautions

- Store refrigerated at 2-8°C (35-45°F). Do not freeze

- For oral use only

- Materials used in administering the vaccine must be free of antibiotic or disinfectant residue to prevent inactivation of Coliprotec® F4

- Do not administer antibiotics or other live vaccines for a minimum of 3 days prior to and after vaccination

- Withdraw antibiotics and disinfectants from drinking water for a minimum of 3 days prior to and after vaccination

- Use entire content when first opened

- Reconstituted vaccine should be used within 4 hours

- Do not vaccinate within 21 days before slaughter

Warning

Anaphylactic reactions may occur. Use epinephrine as antidote. Dispose unused product and empty containers according to local waste disposal requirements.

Coliprotec F4 Dosage And Administration

The Coliprotec® F4 vaccine is administered orally using one dose per pig. Three methods of administration are recommended, being 1) Individual oral administration using a syringe, 2) Conventional drinking water systems and 3) Automatic medicator (proportioner) watering system.

Directions For Administration

Individual administration using a syringe

Do not open or rehydrate the lyophilized vaccine until use. Water used for rehydration or for administration of the vaccine must be free of antibiotic or disinfectant residue to prevent inactivation. Withdraw antibiotics and disinfectants from drinking water for a minimum of 3 days prior to and after vaccination. Rehydrate the lyophilized bacterial culture in the vial using approximately 10 mL (200-dose format or less) or 20 mL (format of more than 200 doses) of water. Shake well. Transfer the vaccine to a sterile graduated sterile container. Rinse the bottle with another 10 mL of water and transfer to the same container. DILUTE THE VACCINE IN THE CONTAINER USING WATER TO OBTAIN A FINAL VOLUME OF 3 ML PER DOSE. Using a syringe, administer a 3-mL oral single dose of the vaccine preparation per pig.

Conventional drinking water system

Do not open or rehydrate the lyophilized vaccine until use. Water used for rehydration or for administration of the vaccine must be free of antibiotic or disinfectant residue to prevent inactivation. Withdraw antibiotics and disinfectants from drinking water for a minimum of 3 days prior to and after vaccination. Flush the watering system with untreated water. Withhold water for 1 to 2 hours immediately before vaccination. Ensure that pigs can drink in 4 hours by providing watering space so that all the pigs can drink easily.

On the day prior to vaccination, determine the volume (mL) of water consumed within 4 hours, by the number of pigs to be treated. If the information is not available, please refer to the reference table below. Rehydrate the lyophilized bacterial culture in the vial using approximately 10 mL (200-dose format or less) or 20 mL (format of more than 200 doses) of water. Shake well. Transfer the vaccine to a sterile container. Rinse the vial with another 10 mL of tap water and transfer to the same container. Dilute the vaccine with approximately 75% of the determined volume of water. Add the bacterial suspension to the drinking water tanks for the appropriate number of pigs. The rehydrated culture should be consumed within 4 hours.

Automatic medicator watering system

Do not open or rehydrate the lyophilized vaccine until use. Water used for rehydration or for administration of the vaccine must be free of antibiotic or disinfectant residue to prevent inactivation. Withdraw antibiotics and disinfectants from drinking water for a minimum of 3 days prior to and after vaccination. Flush the watering system with untreated water. Withhold water for 1 to 2 hours immediately before vaccination. Ensure that pigs can drink in 4 hours by providing watering space so that all the pigs can drink easily.

Determine the volume of stock solution to be prepared for the number of pigs to treat: On the day prior to vaccination, pre-fill the proportioner container with a known volume of water and determine the volume (mL) consumed within 4 hours by the number of pigs to be treated. If the information is not available, please refer to the reference table below. Select the volume of the proportioner for 30 mL of stock solution per 4 liters of water (1 oz per gallon). Many proportioners are factory set at 1:128 to deliver 1 oz per gallon of water.

Prepare the stock solution of culture: Use the number of doses equal to the number of pigs to be treated. Rehydrate the lyophilized bacterial culture in the vial using approximately 10 mL (200-dose format or less) or 20 mL (format of more than 200 doses) of water. Shake well. Transfer the vaccine to the proportioner container. Rinse the vial with another 10 mL of water and transfer to the same container. Add the appropriate volume of water to reach the determined volume of stock solution. Mix well. Insert the tube of the proportioner into the stock solution (vaccine preparation) and open the water system. The rehydrated culture should be consumed within 4 hours.

Reference Table For Water Consumption

Water consumption is affected by environmental temperature, management conditions, and the age of pigs. The following table serves as a guideline.

Body weight

Water consumption per 100 pigs in a 4-hour period

Volume of stock solution to be prepared per 100 pigs1

4.5 Kg

11 L

85 mL

6.8 Kg

17 L

130 mL

9.0 Kg

23 L

175 mL

1Proportioner set at 30 mL per 4 liters (1 oz per gallon)

Manufactured for Prevtec microbia Inc, 3395, Casavant Blvd. West • Saint-Hyacinthe (Québec) • Canada • J2S 0B8

Tel: 450-774-7000 • Fax: 450-774-8777

Manufactured by Diamond Animal Health, Inc., Des Moines • Iowa • 50327 • U.S.A.

Distributed by Elanco Division Eli Lilly Canada, Inc., 150, Research Lane, Suite 120 • Guelph • Ontario • Canada • N1G 4T2

COLIPROTEC® is a registered trademark of Prevtec microbia Inc., used under license.

PKI-RA-0008 v02

Code

Format

COL-0200

200 doses

COL-0500

500 doses

NAC No.: 1331000.3

PREVTEC MICROBIA INC
3395 CASAVANT BLVD. W, SAINT-HYACINTHE, QC, J2S 0B8
Telephone:   1-450-774-7000
Toll-Free:   1-866-774-7003
Order Desk:   1-800-773-7603
Fax:   1-450-774-8777
Website:   www.prevtecmicrobia.com
Email:   info@prevtecmicrobia.com
Every effort has been made to ensure the accuracy of the Coliprotec F4 information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert.

Copyright © 2016 North American Compendiums. Updated: 2016-08-21

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