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Adequan i.m. Single Dose

This page contains information on Adequan i.m. Single Dose for veterinary use.
The information provided typically includes the following:
  • Adequan i.m. Single Dose Indications
  • Warnings and cautions for Adequan i.m. Single Dose
  • Direction and dosage information for Adequan i.m. Single Dose

Adequan i.m. Single Dose

This treatment applies to the following species:
Company: American Regent

polysulfated glycosaminoglycan

Solution 500 mg/5 mL

For Intramuscular Use In Horses

Adequan i.m. Single Dose Caution

Federal law restricts this drug to use by or on the order of a licensed veterinarian.


Each 5 milliliters of Adequan® i.m. contains 500 mg of Polysulfated Glycosaminoglycan (PSGAG) and Water for Injection q.s. Sodium Hydroxide and/or Hydrochloric Acid added when necessary to adjust pH. Sodium Chloride may be added to adjust tonicity.


Polysulfated Glycosaminoglycan is chemically similar to the glycosaminoglycans in articular cartilage matrix. PSGAG is a potent proteolytic enzyme inhibitor and diminishes or reverses the pathologic processes of traumatic or degenerative joint disease which result in a net loss of cartilage matrix components. PSGAG improves joint function by reducing synovial fluid protein levels and increasing synovial fluid hyaluronic acid concentration in traumatized equine carpal and hock joints.

Adequan i.m. Single Dose Indications

Adequan® i.m. is recommended for the intramuscular treatment of non-infectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal and hock joints in horses.

Dosage and Administration

The recommended dose of Adequan® i.m. in horses is 500 mg every 4 days for 28 days intramuscularly. The injection site must be thoroughly cleansed prior to injection. Do not mix Adequan® i.m. with other drugs or solvents.


There are no known contraindications to the use of intramuscular Polysulfated Glycosaminoglycan.


Do not use in horses intended for human consumption. Not for use in humans. Keep this and all medications out of the reach of children.


The safe use of Adequan® i.m. in horses used for breeding purposes, during pregnancy, or in lactating mares has not been evaluated.

ANIMAL SAFETY: Toxicity studies were conducted in horses. Doses as high as 2,500 mg were administered intramuscularly to 6 horses twice a week for 12 weeks. This dosage is 5 times the recommended dosage and 3 times the recommended therapeutic regimen. Clinical observations revealed no soreness or swelling at the injection site or in the affected joint. No animal had any clinical or laboratory evidence of toxicity.

STORAGE CONDITIONS: Store at 20°-25°C (68°-77°F); (See USP Controlled Room Temperature). Discard unused portion.

Dispose of spent needles in accordance with all federal, state and local environmental laws.

How Supplied

Adequan® i.m. solution, 500 mg/5 mL (100 mg/mL) in a 5 mL single dose glass vial.

NDC 10797-995-70 5 mL

5 mL Single Dose Vials

Packaged 7 vials per box



Approved by FDA under NADA # 140-901

Made in U.S.A.


Rev. 9/2021

MG #44455

CPN: 1039002.9

Animal Health Division

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