Dexamethasone: 6 things you should know
Medically reviewed by C. Fookes, BPharm. Last updated on Jan 28, 2019.
1. How it works
- Dexamethasone may be used in the treatment of conditions characterized by inflammation. Dexamethasone helps to reduce inflammation and calms down an overactive immune system.
- Dexamethasone works by mimicking the effect of cortisol, a hormone released by the adrenal glands (which are located on top of the kidneys) that controls metabolism and stress.
- Dexamethasone belongs to the class of medicines known as corticosteroids. It is specifically a glucocorticoid.
- May be used to help control inflammation associated with a wide range of conditions, such as skin diseases, endocrine disorders, ulcerative colitis, multiple sclerosis, blood disorders, nerve disorders, eye disease, renal disease, respiratory disease, rheumatic disease, and in palliative care.
- Usually only prescribed for short-term use; however, in certain instances, dexamethasone may be prescribed for longer periods of time.
- Dexamethasone acts similarly to prednisolone but has more potent anti-inflammatory, hormonal, and metabolic effects.
- When given at the same dosage, dexamethasone is less likely than hydrocortisone to cause fluid retention.
- Generic dexamethasone is available.
If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:
- Mood effects such as agitation, anxiety, and irritability; blurred vision; a change in heart rate; swelling of the limbs (sodium and water retention); increased appetite and weight gain; and concentration difficulties are the most common side effects.
- Indigestion, facial hair growth (especially in women), high blood pressure, slow skin healing and skin thinning, osteoporosis (brittle bones), low potassium levels, and problems with blood glucose control may also occur.Rarely, severe allergic reactions have been reported.
- Should not be used in people with systemic fungal infections or with viral infections. Dexamethasone may also increase the risk of infection and its anti-inflammatory action can mask signs of infection.
- May not be suitable for people with certain medical conditions such as heart failure, diabetes, osteoporosis, tuberculosis, cushingoid syndrome, and peptic ulcers.
- Overdosage may cause sodium retention, fluid retention, potassium loss, and weight gain.
- Should not be stopped suddenly if dexamethasone has been used long-term. Reduce dosage gradually over several weeks or months to allow the adrenal glands to return to their normal patterns of secretion. Too rapid a withdrawal of dexamethasone may cause symptoms such as bone and muscle pain, fatigue, weight loss, nausea, and vomiting.
- Alcohol use should be limited or avoided while taking dexamethasone to help prevent stomach ulcers.
- The administration of "live vaccines" needs to be delayed for several months after dexamethasone treatment has stopped.
- May interact with a number of other drugs including aspirin, digoxin, NSAIDs, hormonal contraceptives, other drugs metabolized by CYP 3A4, and warfarin. Dexamethasone may cause low blood potassium levels which may affect how some heart medications work.
Notes: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. For a complete list of all side effects, click here.
- Take exactly as directed, do not increase or decrease the dosage of dexamethasone unless directed by your doctor. Dosage requirements for dexamethasone are variable and must be individualized based on the disease and patient response.
- Limit or avoid alcohol use while taking dexamethasone to help prevent stomach ulcers.
- If you are taking Intensol, an oral solution of dexamethasone, this needs to be mixed with liquid or semi-solid food such applesauce or puddings. Consume the entire amount of the stored product immediately, do not save for future use.
- Seek medical advice as soon as possible if you develop a fever or any other signs of infection while taking dexamethasone. Also, talk to your doctor if you notice any changes with your mood or any other worrying side effects.
- Wear a medical alert bracelet that states you are taking dexamethasone.
- Try to avoid exposing yourself to people with an active viral infection such as chickenpox or measles. Seek medical advice urgently if you think you have been exposed inadvertently.
- Do not stop dexamethasone suddenly if used long-term. Your doctor will advise you how to reduce the dosage of dexamethasone gradually over several weeks or months to allow the adrenal glands to return to their normal patterns of secretion. Too rapid a withdrawal of dexamethasone may cause symptoms such as bone and muscle pain, fatigue, weight loss, nausea, and vomiting.
- Delay the administration of "live vaccines" for several months after dexamethasone treatment has stopped.
- Make sure you inform your dentist or other health professionals that you are taking dexamethasone.
6. Response and Effectiveness
- Peak effects of dexamethasone are reached within 10 to 30 minutes of administration; however, it may take a couple of days before any inflammation is well controlled.
Dexamethasone [Package Insert]. Revised 02/2017. Aidarex Pharmaceuticals LLC https://www.drugs.com/pro/dexamethasone.html
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use dexamethasone only for the indication prescribed.
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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