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Zodryl DAC Side Effects

Generic name: chlorpheniramine / codeine / pseudoephedrine

Medically reviewed by Last updated on Nov 9, 2023.

Note: This document contains side effect information about chlorpheniramine / codeine / pseudoephedrine. Some dosage forms listed on this page may not apply to the brand name Zodryl DAC.

Applies to chlorpheniramine / codeine / pseudoephedrine: oral liquid.


For all patients taking this drug:
  • This drug has an opioid drug in it. Opioid drugs can put you at risk for addiction, abuse, and misuse. Misuse or abuse of this drug can lead to overdose and death. If you have questions, talk with your doctor.
  • This drug has an opioid drug in it. Severe side effects have happened when opioid drugs were used with benzodiazepines or other drugs that may make you drowsy or slow your actions. This includes slow or troubled breathing and death. Benzodiazepines include drugs like alprazolam, diazepam, and lorazepam. Benzodiazepines may be used to treat many health problems like anxiety, trouble sleeping, or seizures. If you have questions, talk with your doctor.
  • Many drugs interact with this drug and can raise the chance of side effects like deadly breathing problems. Talk with your doctor and pharmacist to make sure it is safe to use this drug with all of your drugs.
  • Avoid alcohol or other drugs and natural products that slow your actions.
  • Get medical help right away if you feel very sleepy, very dizzy, or if you pass out. Caregivers or others need to get medical help right away if the patient does not respond, does not answer or react like normal, or will not wake up.
  • Very bad and sometimes deadly breathing problems have happened with this drug. Talk with the doctor.
  • Get medical help right away if you have slow breathing, shallow breathing, or trouble breathing.
  • This drug is not for use in children younger than 18 years of age. The benefits of taking this drug for a cough due to allergies, a cold, or other infection do not outweigh the risks in children. If your child has been given this drug or if you have any questions, talk with your child's doctor.

Serious side effects of Zodryl DAC

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

Other side effects of Zodryl DAC

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to chlorpheniramine/codeine/pseudoephedrine: oral elixir, oral liquid.


The more commonly expected adverse effects include nausea, vomiting, constipation, blurred vision, confusion, dizziness, and headache.[Ref]



Frequency not reported: Respiratory depression, dryness of the pharynx and respiratory passages, laryngismus, atelectasis, wheezing, troubled breathing, hiccups[Ref]

Respiratory depression has been associated with antitussive use of codeine in young children. Respiratory depression and death have occurred in children who received codeine in the postoperative period following tonsillectomy and/or adenoidectomy. Further investigation has shown these patients to be ultra-rapid metabolizers of codeine. Children with obstructive sleep apnea who are treated with codeine appear to be particularly sensitive to the respiratory depressant effects of codeine.[Ref]


Codeine or Chlorpheniramine:

Frequency not reported: Fast, or slow heartbeat, hypertension, hypotension, orthostatic hypotension, palpitations, shock-like state, syncope


Frequency not reported: Tachycardia, palpitations, cardiac arrhythmias, hypertension, impaired circulation to the extremities, coronary artery spasm, chest pain[Ref]

Hypotension is rare and has been reported most frequently with high doses of codeine.

Pseudoephedrine causes vasoconstriction which generally does not produce hypertension, but may be problematic for patients with preexisting hypertension. Arrhythmias may be produced in predisposed patients. Rarely, pseudoephedrine has been reported to cause coronary artery spasm and chest pain.[Ref]


Codeine or Chlorpheniramine:

Frequency not reported: Nausea, vomiting, constipation, abdominal distension, abdominal pain, acute pancreatitis, dry mouth, dyspepsia, epigastric distress, diarrhea, gastro-esophageal reflux, gastrointestinal hypomotility


Frequency not reported: Nausea, vomiting, dry mouth[Ref]



Frequency not reported: Drug dependence, confusion, depression, euphoria, false sense of well-being, excitability, nervousness, agitation, restlessness, insomnia, irritability


Frequency not reported: Hallucinations (particularly in children), anxiety, excitability, insomnia[Ref]

Nervous system

Codeine or Chlorpheniramine:

Frequency not reported: Weakness, dizziness, drowsiness, sedation, headache, facial dyskinesia, lightheadedness, somnolence, dyskinesia, tremor


Frequency not reported: Restlessness, dizziness, weakness, headache, drowsiness, tremor[Ref]

Nearly all patients treated with chlorpheniramine experience drowsiness. This drowsiness may subside in some patients with extended use. Patients should be warned against driving, as well as concomitant ingestion of alcohol and other sedative-hypnotic drugs, while taking chlorpheniramine.

Few cases of dyskinesias and tremors, often of the face, have been reported in patients whose chronic use of chlorpheniramine extended over a period of 3 to 10 years. Some of these cases were only partially relieved by discontinuation of the drug.[Ref]


Codeine or Chlorpheniramine:

Frequency not reported: Ureteral spasm, urinary retention, dysuria, urinary frequency, urinary hesitancy, irritative bladder symptom


Frequency not reported: Urinary retention[Ref]


Codeine or Chlorpheniramine:

Frequency not reported: Allergic laryngospasm, nasal stuffiness, bronchospastic allergic reaction, hives, itching, swelling of face[Ref]


Codeine or Chlorpheniramine:

Frequency not reported: Redness or flushing of face, skin rash, pruritus, erythema, urticaria, excessive perspiration, dermatitis


Frequency not reported: Fixed drug eruption in the form of erythematous nodular patches, rash[Ref]


Codeine or Chlorpheniramine:

Frequency not reported: Decreased lactation, early menses, gynecomastia, increased libido, pheochromocytoma stimulation[Ref]


Codeine or Chlorpheniramine:

Frequency not reported: Changes in glucose utilization, glycosuria, hypoglycemia, increased appetite, loss of appetite[Ref]


Codeine or Chlorpheniramine:

Frequency not reported: Blurred vision, diplopia, visual disturbances, hypermetropia, lacrimation increased, mydriasis, photophobia


Frequency not reported: Angle-closure glaucoma[Ref]


Codeine or Chlorpheniramine:

Frequency not reported: Asthenia, feeling of relaxation, unusual tiredness, labyrinthitis, tinnitus, vertigo[Ref]

More about Zodryl DAC (chlorpheniramine / codeine / pseudoephedrine)

Patient resources

Other brands

Phenylhistine DH

Related treatment guides


1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

2. (2016) "Product Information. Tuzistra XR (chlorpheniramine-codeine)." Vernalis Pharmaceuticals Inc

3. Mariani PJ (1986) "Pseudoephedrine-induced hypertensive emergency: treatment with labetalol." Am J Emerg Med, 4, p. 141-2

4. Rosen RA (1981) "Angina associated with pseudoephedrine ." Ann Emerg Med, 10, p. 230-1

5. Wiener I, Tilkian AG, Palazzolo M (1990) "Coronary artery spasm and myocardial infarction in a patient with normal coronary arteries: temporal relationship to pseudoephedrine ingestion." Cathet Cardiovasc Diagn, 20, p. 51-3

6. "Product Information. Chlor-Trimeton (chlorpheniramine)." Schering-Plough

7. Mores N, Campia U, Navarra P, Cardillo C, Preziosi P (1999) "No cardiovascular effects of single-dose pseudoephedrine in patients with essential hypertension treated with beta-blockers." Eur J Clin Pharmacol, 55, p. 251-4

8. "Product Information. Ryna-C (chlorpheniramine / codeine / pseudoephedrine)." Wallace Laboratories

9. Millet VM, Dreisbach M, Bryson YJ (1982) "Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine." Antimicrob Agents Chemother, 21, p. 1-4

10. Krause LB, Shuster S (1985) "A comparison of astemizole and chlorpheniramine in dermographic urticaria." Br J Dermatol, 112, p. 447-53

11. (1976) "Letter: Dyskinesia associated with chronic antihistamine use." N Engl J Med, 294, p. 113

12. Thach BT, Chase TN, Bosma JF (1975) "Oral facial dyskinesia associated with prolonged use of antihistaminic decongestants." N Engl J Med, 293, p. 486-7

13. Schuller DE, Turkewitz D (1986) "Adverse effects of antihistamines." Postgrad Med, 79, p. 75-86

14. Shelley WB, Shelley ED (1987) "Nonpigmenting fixed drug eruption as a distinctive reaction pattern: examples caused by sensitivity to pseudoephedrine hydrochloride and tetrahydrozoline." J Am Acad Dermatol, 17, p. 403-7

15. Tomb RR, Lepoittevin JP, Espinassouze F, Heid E, Foussereau J (1991) "Systemic contact dermatitis from pseudoephedrine." Contact Dermatitis, 24, p. 86-8

16. Camisa C (1988) "Fixed drug eruption due to pseudoephedrine." Cutis, 41, p. 339-40

17. Quan MB, Chow WC (1996) "Nonpigmenting fixed drug eruption after pseudoephedrine." Int J Dermatol, 35, p. 367-70

18. Vidal C, Prieto A, PerezCarral C, Armisen M (1998) "Nonpigmenting fixed drug eruption due to pseudoephedrine." Ann Allergy Asthma Immunol, 80, p. 309-10

19. Hunskaar S, Dragsund S (1985) "Scarlatiniform rash and urticaria due to codeine." Ann Allergy, 54, p. 240-1

20. (2002) "Product Information. Calcidrine (codeine)." Abbott Pharmaceutical

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.