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Z-Clinz 10 Side Effects

Generic name: benzoyl peroxide / clindamycin topical

Medically reviewed by Last updated on Apr 21, 2024.

Note: This document contains side effect information about benzoyl peroxide / clindamycin topical. Some dosage forms listed on this page may not apply to the brand name Z-Clinz 10.

Applies to benzoyl peroxide/clindamycin topical: external gel, external kit.

Serious side effects of Z-Clinz 10

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

Other side effects of Z-Clinz 10

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to benzoyl peroxide/clindamycin topical: topical gel, topical kit.


The most frequently reported side effects were erythema, scaling, peeling, dry skin, and itching.[Ref]


Very common (10% or more): Erythema (up to 28%), scaling (up to 19%), peeling (up to 17%), dry skin (up to 15%), itching (up to 15%)

Common (1% to 10%): Pruritus, sunburn, burning, stinging

Uncommon (0.1% to 1%): Contact dermatitis, rash, acne worsened

Postmarketing reports: Urticaria[Ref]


Frequency not reported: Colitis

Postmarketing reports: Pseudomembranous colitis, hemorrhagic diarrhea, diarrhea, abdominal pain[Ref]


Postmarketing reports: Anaphylaxis, allergic reaction[Ref]


Common (1% to 10%): Application site reaction

Uncommon (0.1% to 1%): Application site pain, application site exfoliation, application site irritation

Postmarketing reports: Discoloration[Ref]

Nervous system

Common (1% to 10%): Headache

Uncommon (0.1% to 1%): Paresthesia[Ref]


1. (2022) "Product Information. BenzaClin (benzoyl peroxide-clindamycin topical)." Apothecon Inc

2. (2018) "Product Information. Acanya (benzoyl peroxide-clindamycin topical)." Valeant Pharmaceuticals

3. (2018) "Product Information. Duac (benzoyl peroxide-clindamycin topical)." Stiefel Laboratories Inc

4. (2018) "Product Information. Onexton (benzoyl peroxide-clindamycin topical)." Valeant Pharmaceuticals

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.