Vermox Side Effects
Generic name: mebendazole
Medically reviewed by Drugs.com. Last updated on Jun 3, 2024.
Note: This document provides detailed information about Vermox.
Applies to mebendazole: oral tablet chewable Side Effects associated with mebendazole. Some dosage forms listed on this page may not apply specifically to the brand name Vermox.
Applies to mebendazole: oral tablet chewable.
Precautions
It is important that your doctor check your progress at regular visits, especially in infections in which high doses are needed. This is to make sure that the infection is cleared up completely, and to allow your doctor to check for any unwanted effects. Blood tests may be needed.
If your symptoms do not improve after you have taken this medicine for the full course of treatment, or if they become worse, check with your doctor.
Mebendazole can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.
It is important to tell your doctor if you are pregnant before taking this medicine.
For patients taking mebendazole (the active ingredient contained in Vermox) for pinworms:
- Pinworms may be easily passed from one person to another, especially among persons in the same household. Therefore, all household members may have to be treated at the same time to prevent infection or reinfection.
- Some doctors may also recommend other measures to help keep your infection from returning. If you have any questions about this, check with your doctor.
For patients taking mebendazole for hookworms or whipworms:
- In hookworm and whipworm infections, anemia may occur. Therefore, your doctor may want you to take iron supplements to help clear up the anemia.
- It is important to take iron every day during treatment and for 6 months after you stop taking mebendazole. Do not miss any doses. If you have any questions about this, check with your doctor.
In some patients, infections may return after treatment with mebendazole. To help prevent the infection from coming back:
- Wash hands and fingernails often, especially before eating and after using the toilet.
- Wash all fruits and vegetables thoroughly. Cook them well.
- Clean the bedroom floor by vacuuming or damp mopping for several days after treatment with this medicine. Avoid dry sweeping that may stir up the dust.
- Wash (not shake) all beddings and nightclothes (pajamas).
- Wear tight underpants both day and night. Change them daily. Also, wear shoes.
- Use the bathroom and keep the toilet seats clean.
This medicine may cause serious skin reactions when taken together with metronidazole. Check with your doctor right away if you have blistering, peeling, or loose skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using this medicine.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Serious side effects of Vermox
Along with its needed effects, mebendazole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking mebendazole:
Rare side effects
- black, tarry stools
- chills
- convulsions
- cough or hoarseness
- dark urine
- fever with or without chills
- general feeling of tiredness or weakness
- hives or welts, itching, or skin rash
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- light-colored stools
- lower back or side pain
- nausea and vomiting
- painful or difficult urination
- pale skin
- redness of the skin
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- unusual bleeding or bruising
- unusual tiredness or weakness
- upper right abdominal or stomach pain
- yellow eyes and skin
Incidence not known
- blistering, peeling, or loosening of the skin
- diarrhea
- difficulty with swallowing
- dizziness
- fast heartbeat
- joint or muscle pain
- red skin lesions, often with a purple center
- red, irritated eyes
- tightness in the chest
Other side effects of Vermox
Some side effects of mebendazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Rare side effects
- abdominal or stomach pain or upset
Incidence not known
- bloated
- excess air or gas in the stomach or intestines
- full feeling
- hair loss or thinning of the hair
- loss of appetite
- passing gas
- weight loss
For healthcare professionals
Applies to mebendazole: compounding powder, oral tablet chewable.
General adverse events
At the recommended dose, this drug was generally well tolerated; however, patients with high parasitic burdens reported diarrhea and abdominal pain.[Ref]
Gastrointestinal
- Common (1% to 10%): Abdominal pain
- Uncommon (0.1% to 1%): Abdominal discomfort, diarrhea, flatulence
- Frequency not reported: Nausea, vomiting[Ref]
Dermatologic
- Rare (0.01% to 0.1%): Rash
- Frequency not reported: Pruritus
- Postmarketing reports: Toxic epidermal necrolysis, Stevens-Johnson syndrome, exanthema, alopecia, angioedema, urticaria[Ref]
Metabolic
- Frequency not reported: Anorexia[Ref]
Hepatic
- Frequency not reported: Transient changes in liver function tests, granulomatous hepatitis
- Postmarketing reports: Hepatitis, abnormal liver function tests[Ref]
Hematologic
- Frequency not reported: Profound leukopenia, anemia, thrombocytopenia, pancytopenia
- Postmarketing reports: Agranulocytosis, neutropenia[Ref]
Nervous system
- Frequency not reported: Weakness, drowsiness
- Postmarketing reports: Convulsions/seizures, dizziness[Ref]
Renal
- Postmarketing reports: Glomerulonephritis[Ref]
Other
- Frequency not reported: Chills, drug fever, flushing[Ref]
Hypersensitivity
- Postmarketing reports: Hypersensitivity (including anaphylactic reaction, anaphylactoid reaction)[Ref]
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References
1. Barrett-Connor E (1982) "Drugs for the treatment of parasitic infection." Med Clin North Am, 66, p. 245-55
2. Cerner Multum, Inc. "UK Summary of Product Characteristics."
3. Miskovitz PF, Javitt NB (1980) "Leukopenia associated with mebendazole therapy of hydatid disease." Am J Trop Med Hyg, 29, p. 1356-8
4. Kammerer WS, Schantz PM (1984) "Long term follow-up of human hydatid disease (echinococcus granulosus) treated with a high-dose mebendazole regimen." Am J Trop Med Hyg, 33, p. 132-7
5. Bekhti A, Pirotte J (1987) "Hepatotoxicity of mebendazole: relationship with serum concentrations of the drug." Gastroenterol Clin Biol, 11, p. 701-3
6. Witassek F, Bircher (1983) "Chemotherapy of larval echinococcosis with mebendazole: microsomal liver function and cholestasis as determinants of plasma drug level." Eur J Clin Pharmacol, 25, p. 85-90
7. (2002) "Product Information. Vermox (mebendazole)." Janssen Pharmaceuticals
8. Cerner Multum, Inc. "Australian Product Information."
9. Braithwaite PA, Thomas RJ, Thompson RC (1985) "Hydatid disease, the alveolar variety in australia: a case report with comment on the toxicity of mebendazole." Aust N Z J Surg, 55, p. 519-23
10. Colle I, Naegels S, Hoorens A, Hautekeete M (1999) "Granulomatous hepatitis due to mebendazole." J Clin Gastroenterol, 28, p. 44-5
11. Levin MH, Weinstein RA, Axelrod JL, Schantz PM (1983) "Severe, reversible neutropenia during high-dose mebendazole therapy for echinococcosis." JAMA, 249, p. 2929-31
12. Fernandez-Banares F, Gonzalez-Huix F, Xiol X, et al. (1986) "Marrow aplasia during high dose mebendazole treatment." Am J Trop Med Hyg, 35, p. 350-1
13. Murray-Lyon IM, Reynolds KW (1979) "Complication of mebendazole treatment for hydatid disease." Br Med J, 2, p. 1111-2
More about Vermox (mebendazole)
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Further information
Vermox side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.