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Mebendazole Pregnancy and Breastfeeding Warnings

Mebendazole is also known as: Emverm, Vermox

Mebendazole Pregnancy Warnings

Mebendazole has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of fetotoxicity and teratogenicity. There are no controlled data in human pregnancy. However, mebendazole has been used during pregnancy without evidence of fetal harm. Mebendazole is only recommended for use during pregnancy when benefit outweighs risk.

See references

Mebendazole Breastfeeding Warnings

Limited data suggest that mebendazole is poorly excreted into breast milk. Mebendazole is poorly absorbed orally; it is unlikely to adversely affect the breastfed infant or milk production. An informal consultation group to the World Health Organization decided that a single oral dose of mebendazole can be given to lactating women. In 1 report, the peak milk level was 6 mcg/L after a single 100 mg oral dose of mebendazole was given to a nursing mother (time postpartum not stated). Mebendazole was no longer detectable (less than 1 mcg/L) in milk 13.25 hours after the dose. Starting the first day postpartum, 1 woman was given mebendazole 100 mg orally twice a day for 3 days. When measured after treatment (exact timing not stated), mebendazole was undetectable (less than 20 mcg/L) in milk. The authors stated that this result was similar to those reported by the manufacturer and that the infant probably absorbed negligible mebendazole from breast milk.

Caution is recommended. Excreted into human milk: Yes (poorly) Excreted into animal milk: Unknown The effects in the nursing infant are unknown.

See references

References for pregnancy information

  1. Diav-Citrin O, Shechtman S, Arnon J, Lubart I, Ornoy A "Pregnancy outcome after gestational exposure to mebendazole: A prospective controlled cohort study." Am J Obstet Gynecol 188 (2003): 282-5
  2. "Product Information. Vermox (mebendazole)." Janssen Pharmaceutica, Titusville, NJ.
  3. Savioli L, Crompton DW, Neira M "Use of anthelminthic drugs during pregnancy." Am J Obstet Gynecol 188 (2003): 5-6
  4. deSilva NR, Sirisena JLGJ, Gunasekera DPS, Ismail MM, deSilva HJ "Effect of mebendazole therapy during pregnancy on birth outcome." Lancet 353 (1999): 1145-9

References for breastfeeding information

  1. "Product Information. Vermox (mebendazole)." Janssen Pharmaceutica, Titusville, NJ.

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