Vafseo Side Effects

Generic name: vadadustat

Medically reviewed by Drugs.com. Last updated on Nov 10, 2024.

Note: This document provides detailed information about Vafseo Side Effects associated with vadadustat. Some dosage forms listed on this page may not apply specifically to the brand name Vafseo.

Applies to vadadustat: oral tablets film-coated.

Side effects include:

Most common adverse effects (≥10%): hypertension, diarrhea.

For healthcare professionals

Applies to vadadustat: oral tablet.

General adverse events

The most common adverse reactions were thromboembolic events, diarrhea, hypertension, and pneumonia.^[Ref]

Cardiovascular

• Very common (10% or more): Hypertension (up to 14%)
• Common (1% to 10%): Hypotension, atrial fibrillation, arteriovenous fistula thrombosis, arteriovenous fistula site complication, acute myocardial infarction, arteriovenous graft thrombosis
• Uncommon (0.1% to 1%): Deep vein thrombosis, cerebrovascular accident, transient ischemic attack^[Ref]

Gastrointestinal

• Very common (10% or more): Diarrhea (13%)
• Common (1% to 10%): Nausea, vomiting, abdominal pain, gastrointestinal erosion, constipation^[Ref]

Gastrointestinal erosion includes duodenal ulcers and perforation, gastrointestinal ulcers and perforation, esophageal ulcers and perforation, and unspecified site or hematemesis, gastrointestinal hemorrhage, helicobacter duodenitis and gastritis, melena, and gastric hemorrhage.^[Ref]

Hepatic

• Common (1% to 10%): Elevated serum ALT, elevated serum AST
• Uncommon (0.1% to 1%): Elevated bilirubin
• Frequency not reported: Hepatocellular injury with jaundice^[Ref]

Metabolic

• Common (1% to 10%): Fluid overload, hyperkalemia^[Ref]

Musculoskeletal

• Common (1% to 10%): Pain in extremity, back pain^[Ref]

Other

• Very common (10% or more): Death (11.9%)
• Common (1% to 10%): Sepsis, fall, dialysis-related complication^[Ref]

Renal

• Common (1% to 10%): Urinary tract infection, dialysis related complication^[Ref]

Respiratory

• Very common (10% or more): Pneumonia (10.7%)
• Common (1% to 10%): Upper respiratory tract infection, nasopharyngitis, cough, dyspnea
• Uncommon (0.1% to 1%): Pulmonary embolism^[Ref]

Nervous system

• Common (1% to 10%): Headache, seizures^[Ref]

See also:

Further information

Vafseo side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer