Vadadustat Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 10, 2024.

Applies to vadadustat: oral tablets film-coated.

Side effects include:

Most common adverse effects (≥10%): hypertension, diarrhea.

For healthcare professionals

Applies to vadadustat: oral tablet.

General adverse events

The most common adverse reactions were thromboembolic events, diarrhea, hypertension, and pneumonia.^[Ref]

Cardiovascular

• Very common (10% or more): Hypertension (up to 14%)
• Common (1% to 10%): Hypotension, atrial fibrillation, arteriovenous fistula thrombosis, arteriovenous fistula site complication, acute myocardial infarction, arteriovenous graft thrombosis
• Uncommon (0.1% to 1%): Deep vein thrombosis, cerebrovascular accident, transient ischemic attack^[Ref]

Gastrointestinal

• Very common (10% or more): Diarrhea (13%)
• Common (1% to 10%): Nausea, vomiting, abdominal pain, gastrointestinal erosion, constipation^[Ref]

Gastrointestinal erosion includes duodenal ulcers and perforation, gastrointestinal ulcers and perforation, esophageal ulcers and perforation, and unspecified site or hematemesis, gastrointestinal hemorrhage, helicobacter duodenitis and gastritis, melena, and gastric hemorrhage.^[Ref]

Hepatic

• Common (1% to 10%): Elevated serum ALT, elevated serum AST
• Uncommon (0.1% to 1%): Elevated bilirubin
• Frequency not reported: Hepatocellular injury with jaundice^[Ref]

Metabolic

• Common (1% to 10%): Fluid overload, hyperkalemia^[Ref]

Musculoskeletal

• Common (1% to 10%): Pain in extremity, back pain^[Ref]

Other

• Very common (10% or more): Death (11.9%)
• Common (1% to 10%): Sepsis, fall, dialysis-related complication^[Ref]

Renal

• Common (1% to 10%): Urinary tract infection, dialysis related complication^[Ref]

Respiratory

• Very common (10% or more): Pneumonia (10.7%)
• Common (1% to 10%): Upper respiratory tract infection, nasopharyngitis, cough, dyspnea
• Uncommon (0.1% to 1%): Pulmonary embolism^[Ref]

Nervous system

• Common (1% to 10%): Headache, seizures^[Ref]

See also:

Further information

Vadadustat side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer