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Vadadustat Dosage

Medically reviewed by Drugs.com. Last updated on Apr 22, 2025.

Usual Adult Dose for Anemia Associated with Chronic Renal Failure

Initial dose: 300 mg orally once a day
Maximum dose: 600 mg orally once a day

Comments:


Use: For the treatment of anemia due to chronic kidney disease in patients who have been in dialysis for at least 3 months

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Mild or Moderate Liver Dysfunction (Child-Pugh Class A or B): No adjustment recommended.
Severe Liver Dysfunction (Child-Pugh Class C): Not recommended.

Dose Adjustments

Dose adjustment should be done in increments of 150 mg within the range of 150 mg to a maximum daily dose of 600 mg orally once a day to achieve or maintain hemoglobin (Hb) levels within 10 to 11 g/dL. A single Hb excursion may not require a dosing change.

Consider the following conditions when adjusting the dose:


For Hb levels that rapidly rise (e.g., more than 1 g/dL in any 2-week period or more than 2 g/dL in 4 weeks): Therapy should be interrupted, or the dose reduced.

For Hb level exceeding 11 g/dL: Therapy should be interrupted until Hb is 11 g/dL or less. This drug should be restarted at a dose that is 150 mg less than the dose prior to interruption.

CONVERTING FROM ERYTHROPOIESIS-STIMULATING AGENT (ESA):


DOSE ADJUSTMENT TO PREVENT DRUG INTERACTIONS
Oral Iron and Phosphate Binders:

Precautions

US BOXED WARNING(S):
Increased Risk of Death, Myocardial Infarction, Stroke, Venous Thromboembolism, and Thrombosis of Vascular Access:


CONTRAINDICATIONS:

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Other Comments

Administration advice:


Storage requirements:

General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.