Tolak Side Effects
Generic Name: fluorouracil topical
Note: This page contains side effects data for the generic drug fluorouracil topical. It is possible that some of the dosage forms included below may not apply to the brand name Tolak.
For the Consumer
Applies to fluorouracil topical: topical cream, topical solution
As well as its needed effects, fluorouracil topical (the active ingredient contained in Tolak) may cause unwanted side effects that require medical attention.
Major Side Effects
If any of the following side effects occur while taking fluorouracil topical, check with your doctor immediately:
- Redness and swelling of normal skin
Minor Side Effects
Some fluorouracil topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common:
- Burning feeling where medicine is applied
- increased sensitivity of skin to sunlight
- skin rash
- soreness or tenderness of skin
- Darkening of skin
- watery eyes
For Healthcare Professionals
Applies to fluorouracil topical: topical cream, topical kit, topical solution
Very rare (less than 0.01%): Pruritus, urticaria, rash (local or generalized), erythema (i.e., erythema multiforme), burning sensation, exfoliation, swelling, ulceration, allergic contact dermatitis, eczema, blistering, alopecia, pain
Frequency not reported: Hyperpigmentation, crusting, irritation, photosensitivity, scarring, bullous pemphigoid, ichthyosis, scaling, suppuration, telangiectasia, tenderness, herpes simplex[Ref]
Very rare (less than 0.01%): Diarrhea, vomiting, abdominal pain, stomatitis, mucosal inflammation
Frequency not reported: Nausea, medicinal taste[Ref]
Frequency not reported: Leukocytosis, eosinophilia, thrombocytopenia, toxic granulation[Ref]
Very rare (less than 0.01%): Hypersensitivity[Ref]
Frequency not reported: Dysgeusia, headache, dizziness[Ref]
Frequency not reported: Conjunctival irritation, corneal reaction, keratitis, increased lacrimation[Ref]
Very rare (less than 0.01%): Pyrexia, chills[Ref]
Frequency not reported: Nasal irritation[Ref]
Frequency not reported: Emotional upset, irritability, insomnia[Ref]
1. "Product Information. Tolak (fluorouracil topical)." Hill Dermaceuticals Inc, Sanford, FL.
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. Cerner Multum, Inc. "Australian Product Information." O 0
4. "Product Information. Fluoroplex (fluorouracil topical)." Aqua Pharmaceuticals LLC, Malvern, PA.
5. "Product Information. Fluorouracil Topical (fluorouracil topical)." A-S Medication Solutions, Chicago, IL.
6. "Product Information. Efudex (fluorouracil topical)." Valeant Pharmaceuticals, Costa Mesa, CA.
It is possible that some side effects of Tolak may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
More about Tolak (fluorouracil topical)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Support Group
- Pricing & Coupons
- En Español
- 2 Reviews – Add your own review/rating
- Drug class: topical antineoplastics
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