Skip to Content

Tolak Side Effects

Generic Name: fluorouracil topical

Note: This page contains side effects data for the generic drug fluorouracil topical. It is possible that some of the dosage forms included below may not apply to the brand name Tolak.

For the Consumer

Applies to fluorouracil topical: topical cream, topical solution

As well as its needed effects, fluorouracil topical (the active ingredient contained in Tolak) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking fluorouracil topical, check with your doctor immediately:

  • Redness and swelling of normal skin

Minor Side Effects

Some fluorouracil topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Burning feeling where medicine is applied
  • increased sensitivity of skin to sunlight
  • itching
  • oozing
  • skin rash
  • soreness or tenderness of skin
Less common or rare:
  • Darkening of skin
  • scaling
  • watery eyes

For Healthcare Professionals

Applies to fluorouracil topical: topical cream, topical kit, topical solution

Dermatologic

Very rare (less than 0.01%): Pruritus, urticaria, rash (local or generalized), erythema (i.e., erythema multiforme), burning sensation, exfoliation, swelling, ulceration, allergic contact dermatitis, eczema, blistering, alopecia, pain
Frequency not reported: Hyperpigmentation, crusting, irritation, photosensitivity, scarring, bullous pemphigoid, ichthyosis, scaling, suppuration, telangiectasia, tenderness, herpes simplex[Ref]

Gastrointestinal

Very rare (less than 0.01%): Diarrhea, vomiting, abdominal pain, stomatitis, mucosal inflammation
Frequency not reported: Nausea, medicinal taste[Ref]

Hematologic

Frequency not reported: Leukocytosis, eosinophilia, thrombocytopenia, toxic granulation[Ref]

Hypersensitivity

Very rare (less than 0.01%): Hypersensitivity[Ref]

Nervous system

Frequency not reported: Dysgeusia, headache, dizziness[Ref]

Ocular

Frequency not reported: Conjunctival irritation, corneal reaction, keratitis, increased lacrimation[Ref]

Other

Very rare (less than 0.01%): Pyrexia, chills[Ref]

Respiratory

Frequency not reported: Nasal irritation[Ref]

Psychiatric

Frequency not reported: Emotional upset, irritability, insomnia[Ref]

References

1. "Product Information. Tolak (fluorouracil topical)." Hill Dermaceuticals Inc, Sanford, FL.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

4. "Product Information. Fluorouracil Topical (fluorouracil topical)." A-S Medication Solutions, Chicago, IL.

5. "Product Information. Efudex (fluorouracil topical)." Valeant Pharmaceuticals, Costa Mesa, CA.

6. "Product Information. Fluoroplex (fluorouracil topical)." Aqua Pharmaceuticals LLC, Malvern, PA.

It is possible that some side effects of Tolak may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide