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Tepadina Side Effects

Generic name: thiotepa

Medically reviewed by Drugs.com. Last updated on Feb 10, 2024.

Note: This document provides detailed information about Tepadina Side Effects associated with thiotepa. Some dosage forms listed on this page may not apply specifically to the brand name Tepadina.

Applies to thiotepa: injection powder for solution.

Serious side effects of Tepadina

Along with its needed effects, thiotepa (the active ingredient contained in Tepadina) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking thiotepa:

More common side effects

  • bleeding gums
  • blood in the urine
  • blurred or double vision
  • confusion
  • coughing up blood
  • cracked lips
  • diarrhea
  • difficulty with breathing or swallowing
  • difficulty with walking
  • dizziness
  • drooping eyelids
  • headache, sudden, severe
  • increased menstrual flow or vaginal bleeding
  • jaw pain
  • nausea and vomiting
  • nosebleeds
  • numbness or tingling in the fingers and toes
  • pain in the fingers and toes
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • sores, ulcers, or white spots on the lips, tongue, or inside the mouth
  • weakness

Incidence not known

  • absent, missed, or irregular menstrual periods
  • blistering, peeling, or loosening of the skin
  • bloated abdomen
  • cough or hoarseness
  • fast heartbeat
  • fever or chills
  • hives or welts, itching, or skin rash
  • joint or muscle pain
  • lower back or side pain
  • pain and fullness in the right upper abdomen or stomach
  • painful or difficult urination
  • pale skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • redness of the skin
  • stopping of menstrual bleeding
  • tightness in the chest
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weight gain
  • yellow eyes and skin

Other side effects of Tepadina

Some side effects of thiotepa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • abdominal or stomach pain
  • blistering, burning, crusting, dryness, or flaking of the skin
  • hair loss or thinning of the hair
  • itching, scaling, severe redness, soreness, or swelling of the skin
  • loss of appetite
  • pain at the injection site
  • stopping of menstrual bleeding
  • weight loss

For healthcare professionals

Applies to thiotepa: injectable powder for injection, intravenous powder for injection.

Hematologic adverse events

Granulocytopenia

thromboembolism, venous thromboembolism[Ref]

Oncologic

leukemia[Ref]

Hypersensitivity

Local

Gastrointestinal

Renal

Respiratory

Nervous system

Dermatologic

Genitourinary

Ocular

Other

Immunologic

Musculoskeletal

Metabolic

Psychiatric

Hepatic

Glutamyltransferase, increased blood alkaline, phosphatase increased, aspartate aminotransferase increased[Ref]

Cardiovascular

Endocrine

References

1. (2001) "Product Information. Thiotepa (thiotepa)." Hikma USA (formerly West-Ward Pharmaceutical Corporation)

2. Cerner Multum, Inc. "Australian Product Information."

Further information

Tepadina side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.