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Tavalisse Side Effects

Generic name: fostamatinib

Medically reviewed by Philip Thornton, DipPharm. Last updated on Dec 17, 2022.

Note: This document contains side effect information about fostamatinib. Some dosage forms listed on this page may not apply to the brand name Tavalisse.

Applies to fostamatinib: oral tablet.


Fostamatinib can raise your blood pressure, sometimes to dangerous levels. Fostamatinib may also cause liver problems, severe diarrhea, and infections.

Call your doctor if you have: headaches, chest pain, shortness of breath, severe diarrhea, stomach pain, fever, or sore throat.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe diarrhea;

  • stomach pain (upper right side);

  • dark urine, jaundice (yellowing of the skin or eyes);

  • headaches, chest pain, shortness of breath; or

  • fever, sore throat, or other signs of infection.

Your fostamatinib (the active ingredient contained in Tavalisse) doses may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to fostamatinib: oral tablet.


Common (1% to 10%): Neutropenia[Ref]


Very common (10% or more): ALT increased (11%)

Common (1% to 10%): AST increased[Ref]


Very common (10% or more): Respiratory infection (11%)[Ref]


Common (1% to 10%): Fatigue[Ref]

Nervous system

Very common (10% or more): Dizziness (11%)[Ref]


Very common (10% or more): Hypertension (28%)[Ref]


Common (1% to 10%): Rash (e.g., rash erythematous, rash macular)[Ref]


Very common (10% or more): Diarrhea (31%), nausea (19%)

Common (1% to 10%): Abdominal pain[Ref]


1. "Product Information. Tavalisse (fostamatinib)." Rigel Pharmaceuticals (2018):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.