Tagraxofusp Side Effects

Medically reviewed by Drugs.com. Last updated on Dec 25, 2023.

Applies to tagraxofusp: intravenous solution.

Important warnings This medicine can cause some serious health issues

Intravenous route (solution)

Capillary Leak Syndrome (CLS) which may be life-threatening or fatal, can occur in patients receiving tagraxofusp-erzs.

Monitor for signs and symptoms of CLS and take actions as recommended

Serious side effects of tagraxofusp

Along with its needed effects, tagraxofusp may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking tagraxofusp:

More common

• black, tarry stools
• bloating or swelling of the face, arms, hands, lower legs, or feet
• bloody or cloudy urine
• blurred vision
• chest tightness
• chills
• confusion
• cough
• decrease or increase in the amount of urine
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• fast, pounding, or irregular heartbeat or pulse
• fever
• headache
• itching skin
• lower back or side pain
• nausea
• nervousness
• nosebleed
• painful or difficult urination
• pale skin
• pounding in the ears
• rapid weight gain
• slow heartbeat
• small red or purple spots on the skin
• sore throat
• stomach pain
• sweating
• tingling of the hands or feet
• trouble breathing
• ulcers, sores, or white spots in the mouth
• unusual bleeding or bruising
• unusual tiredness or weakness
• unusual weight gain or loss

Less common

• clay colored stools
• dark urine
• decreased appetite
• loss of appetite
• stomach tenderness
• swelling of the feet or lower legs
• vomiting
• yellow eyes or skin

Other side effects of tagraxofusp

Some side effects of tagraxofusp may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• anxiety
• arm, back, or leg pain
• constipation
• diarrhea
• mouth or throat pain
• trouble sleeping

For healthcare professionals

Applies to tagraxofusp: intravenous solution.

General

The most common laboratory abnormalities (incidence 50% or greater) are decreases in albumin, platelets, hemoglobin, calcium, and sodium and increases in glucose, ALT, and AST.

The most common adverse reactions (incidence 30% or greater) are capillary leak syndrome (CSL), nausea, fatigue, peripheral edema, pyrexia, and weight increase.^[Ref]

Hypersensitivity

• Very common (10% or more): Hypersensitivity (46%)^[Ref]

Immunologic

• Frequency not reported: Immunogenicity^[Ref]

Metabolic

• Very common (10% or more): Increased glucose (67%), decreased calcium (57%), decreased sodium (50%), decreased potassium (39%), decreased phosphate (30%), increased alkaline phosphatase (26%), decreased appetite (24%), increased potassium (21%), decreased magnesium (14%), decreased glucose (11%), increased sodium (10%)^[Ref]

Psychiatric

• Very common (10% or more): Insomnia (17%), anxiety (15%), confusion (11%)^[Ref]

Hepatic

• Very common (10% or more): Elevated liver enzymes (Grade 1 or 2 in 48%, Grade 3 in 36%, Grade 4 in 4%) (88%), ALT increase (82%), AST increase (79%)^[Ref]

Respiratory

• Very common (10% or more): Dyspnea (19%), cough (14%), epistaxis (14%), oropharyngeal pain (12%)^[Ref]

Other

• Very common (10% or more): Fatigue (45%), peripheral edema (43%), pyrexia (43%), weight increase (31%), chills (29%)^[Ref]

Hematologic

• Very common (10% or more): Decreased platelets (67%), decreased hemoglobin (60%), decreased neutrophils (37%)^[Ref]

Nervous system

• Very common (10% or more): Headache (29%), dizziness (20%)^[Ref]

Renal

• Very common (10% or more): Hematuria (10%), decreased creatinine (27%)^[Ref]

Cardiovascular

• Very common (10% or more): Capillary leak syndrome (55%), hypotension (29%), tachycardia (17%), hypertension (15%)^[Ref]

Dermatologic

• Very common (10% or more): Petechiae (10%), pruritus (10%)^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (49%), constipation (23%), vomiting (21%), diarrhea (20%)^[Ref]

Frequently asked questions

• What disease is Elzonris (tagraxofusp-erzs) used to treat?

Further information

Tagraxofusp side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer