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Fludarabine (injection)

Generic name: fludarabine (injection) [ floo-DAR-a-been ]
Dosage forms: intravenous powder for injection (50 mg), intravenous solution (25 mg/mL)
Drug class: Antimetabolites

Medically reviewed by on Jul 27, 2023. Written by Cerner Multum.

What is fludarabine?

Fludarabine is used to treat B-cell chronic lymphocytic leukemia (CLL).

Fludarabine is usually given after other treatments have failed.

Fludarabine may also be used for purposes not listed in this medication guide.

Fludarabine side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

In rare cases, fludarabine may cause serious side effects on your nervous system. Seek medical attention right away if you have any numbness or tingling, burning pain, or vision problems.

Fludarabine may cause serious side effects. Call your doctor at once if you have:

Common side effects of fludarabine may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


In rare cases, fludarabine may cause serious side effects on your nervous system. Seek medical attention right away if you have any numbness or tingling, burning pain, or vision problems.

Fludarabine may also cause serious side effects on your red blood cells. Call your doctor right away if you feel weak or confused, or if you have pale or yellowed skin, or dark urine.

Before taking this medicine

You should not be treated with fludarabine if you are allergic to it.

Tell your doctor if you have ever had:

Fludarabine may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

You should not breastfeed while you are receiving fludarabine.

How is fludarabine given?

Fludarabine is given as an infusion into a vein. A healthcare provider will give you this injection.

Fludarabine is given in a 28-day treatment cycle. You may need to use the medicine only during the first 5 days of each cycle. Your doctor will determine how long to treat you with fludarabine.

This medicine must be given slowly, and the infusion can take at least 30 minutes to complete.

Fludarabine can be harmful if it gets in your eyes, mouth, or nose, or on your skin. If skin contact occurs, wash the area with soap and water or rinse the eyes thoroughly with plain water.

Fludarabine can increase your risk of bleeding or infection. You will need frequent medical tests. Your cancer treatments may be delayed based on the results.

If you need to have a blood transfusion, tell your caregivers ahead of time that you are being treated with fludarabine.

Fludarabine dosing information

Usual Adult Dose for Chronic Lymphocytic Leukemia:

25 mg/m2 IV over 30 minutes for 5 days every 28 days; following a maximal tumor response, 3 additional cycles are recommended

-The optimal duration of treatment has not been clearly established.
-The dose may be decreased or delayed for hematologic or nonhematologic toxicity.
-Physicians should consider delaying or discontinuing the drug if neurotoxicity occurs.

Use: For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen; the safety and effectiveness of this drug in previously untreated or nonrefractory patients with CLL have not been established

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your fludarabine injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include fever, flu-like symptoms, numbness or tingling, vision loss, or loss of consciousness.

What should I avoid while receiving fludarabine?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Do not receive a "live" vaccine while using fludarabine, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

What other drugs will affect fludarabine?

Other drugs may affect fludarabine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.