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Symlin Pen Side Effects

Generic name: pramlintide

Medically reviewed by Last updated on Oct 31, 2023.

Note: This document contains side effect information about pramlintide. Some dosage forms listed on this page may not apply to the brand name Symlin Pen.

Applies to pramlintide: subcutaneous solution.


Subcutaneous route (Solution)

Severe hypoglycemia has occurred within 3 hours of pramlintide injection when used concomitantly with insulin, especially in patients with type 1 diabetes. Serious injuries may happen if hypoglycemia occurs during high-risk activities, and appropriate patient selection, instruction, and insulin dose reduction are critical for reducing this risk.

Serious side effects of Symlin Pen

Along with its needed effects, pramlintide (the active ingredient contained in Symlin Pen) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pramlintide:

More common

Other side effects of Symlin Pen

Some side effects of pramlintide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to pramlintide: subcutaneous solution.


Very common (10% or more): Severe hypoglycemia (up to 16.8%), anorexia (up to 17%)[Ref]


Very common (10% or more): Nausea (up to 48%), vomiting (up to 11%)

Common (1% to 10%): Abdominal pain

Frequency not reported: Slower gastric emptying

Postmarketing reports: Pancreatitis[Ref]


Common (1% to 10%): Allergic reaction[Ref]

Nervous system

Very common (10% or more): Headache

Common (1% to 10%): Dizziness[Ref]


Common (1% to 10%): Arthralgia[Ref]


Common (1% to 10%): Cough, pharyngitis[Ref]


The most commonly reported side effects were: nausea, vomiting, and severe hypoglycemia.[Ref]


Postmarketing reports: Injection site reactions[Ref]


Very common (10% or more): Inflicted injury (14%)

Common (1% to 10%): Fatigue[Ref]

More about Symlin Pen (pramlintide)

Patient resources

Other brands

SymlinPen 120, SymlinPen 60

Professional resources

Other formulations

Related treatment guides


1. Product Information. Symlin (pramlintide). Amphastar Pharmaceuticals Inc. 2005.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.