Symlin Pen Side Effects

Generic name: pramlintide

Medically reviewed by Drugs.com. Last updated on Mar 19, 2025.

Note: This document provides detailed information about Symlin Pen Side Effects associated with pramlintide. Some dosage forms listed on this page may not apply specifically to the brand name Symlin Pen.

Applies to pramlintide: subcutaneous solution.

Important warnings This medicine can cause some serious health issues

Subcutaneous route (solution)

Severe hypoglycemia has occurred within 3 hours of pramlintide injection when used concomitantly with insulin, especially in patients with type 1 diabetes.

Serious injuries may happen if hypoglycemia occurs during high-risk activities, and appropriate patient selection, instruction, and insulin dose reduction are critical for reducing this risk.

Serious side effects of Symlin Pen

Along with its needed effects, pramlintide (the active ingredient contained in Symlin Pen) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pramlintide:

More common side effects

• anxiety
• blurred vision
• chills
• cold sweats
• coma
• confusion
• cool pale skin
• cough
• depression
• difficulty with swallowing
• dizziness
• fast heartbeat
• headache
• hives, itching, or skin rash
• increased hunger
• nausea
• nightmares
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• seizures
• shakiness
• slurred speech
• tightness in the chest
• unusual tiredness or weakness

Other side effects of Symlin Pen

Some side effects of pramlintide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• difficulty with moving
• inflicted injury
• loss of appetite
• muscle pain or stiffness
• pain in the joints
• stomach pain
• vomiting
• weight loss

Less common side effects

• body aches or pain
• congestion
• dryness or soreness of the throat
• fever
• hoarseness
• runny nose
• tender, swollen glands in the neck
• voice changes

For healthcare professionals

Applies to pramlintide: subcutaneous solution.

General adverse events

The most commonly reported side effects were: nausea, vomiting, and severe hypoglycemia.^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (up to 48%), vomiting (up to 11%)
• Common (1% to 10%): Abdominal pain
• Frequency not reported: Slower gastric emptying
• Postmarketing reports: Pancreatitis^[Ref]

Hypersensitivity

• Common (1% to 10%): Allergic reaction^[Ref]

Nervous system

• Very common (10% or more): Headache
• Common (1% to 10%): Dizziness^[Ref]

Musculoskeletal

• Common (1% to 10%): Arthralgia^[Ref]

Respiratory

• Common (1% to 10%): Cough, pharyngitis^[Ref]

Metabolic

• Very common (10% or more): Severe hypoglycemia (up to 16.8%), anorexia (up to 17%)^[Ref]

Local

• Postmarketing reports: Injection site reactions^[Ref]

Other

• Very common (10% or more): Inflicted injury (14%)
• Common (1% to 10%): Fatigue^[Ref]

Further information

Symlin Pen side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer