SSD AF Side Effects
Generic Name: silver sulfadiazine topical
Medically reviewed by Drugs.com. Last updated on Nov 4, 2020.
Note: This document contains side effect information about silver sulfadiazine topical. Some of the dosage forms listed on this page may not apply to the brand name SSD AF.
For the Consumer
Applies to silver sulfadiazine topical: topical cream
Side effects requiring immediate medical attention
Along with its needed effects, silver sulfadiazine topical (the active ingredient contained in SSD AF) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking silver sulfadiazine topical:
Incidence not known
- Back, leg, or stomach pains
- blistering, peeling, or loosening of the skin
- blue-green to black skin discoloration
- dark urine
- fever with or without chills
- general body swelling
- increased sensitivity of the skin to sunlight, especially in patients with burns on large areas
- intense itching of burn wounds
- light-colored stools
- lower back or side pain
- nausea or vomiting
- pinpoint red spots on the skin
- red skin lesions, often with a purple center
- red, swollen skin
- skin rash
- sores, ulcers, or white spots in the mouth or on the lips
- swollen or painful glands
- unusual bleeding or bruising
- unusual tiredness or weakness
- upper right abdominal or stomach pain
- yellow eyes and skin
Side effects not requiring immediate medical attention
Some side effects of silver sulfadiazine topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
- Brownish-gray skin discoloration
- burning feeling on treated areas
For Healthcare Professionals
Applies to silver sulfadiazine topical: compounding powder, topical cream
Common (1% to 10%): Leukopenia
Rare (less than 0.1%): Argyria
Very rare (less than 0.01%): Renal failure
Frequency not reported: Interstitial nephritis[Ref]
Frequency not reported: Hepatitis, hepatocellular necrosis[Ref]
Frequency not reported: Central nervous system reactions[Ref]
Frequency not reported: Gastrointestinal reactions
1. "Product Information. Silvadene (silver sulfadiazine topical)." Pfizer U.S. Pharmaceuticals Group, New York, NY.
More about SSD AF (silver sulfadiazine topical)
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.