Sonidegib Side Effects

Medically reviewed by Drugs.com. Last updated on Jul 25, 2024.

Applies to sonidegib: oral capsule.

Important warnings This medicine can cause some serious health issues

Oral route (capsule)

Use of sonidegib during pregnancy can cause embryofetal death or severe birth defects.

Verify pregnancy status prior to initiating treatment and advise females of reproductive potential to use adequate contraception during treatment and for at least 20 months after discontinuation.

Male patients with a female partner of reproductive potential must be advised to use adequate contraception during treatment for at least 8 months after discontinuation.

Serious side effects of sonidegib

Along with its needed effects, sonidegib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sonidegib:

More common side effects

• difficulty with moving
• joint pain
• muscle aching or cramping
• muscle pains or stiffness
• muscle spasms
• swollen joints

Rare side effects

• dark-colored urine
• fever
• muscle stiffness
• unusual tiredness or weakness

Other side effects of sonidegib

Some side effects of sonidegib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• abdominal or stomach pain
• change in taste
• decreased appetite
• decreased weight
• diarrhea
• hair loss or thinning of the hair
• headache
• itching skin
• loss of taste
• nausea
• vomiting

For healthcare professionals

Applies to sonidegib: oral capsule.

Musculoskeletal adverse events

• Very common (10% or more): Increased serum creatinine (92%), increased serum creatinine kinase (61%), muscle spasms (54%), musculoskeletal pain (32%), myalgia (19%)
• Uncommon (0.1% to 1%): Rhabdomyolysis^[Ref]

75% of patients with increased serum creatinine had levels that remained within normal range.^[Ref]

Dermatologic

• Very common (10% or more): Alopecia (53%), pruritus (10%)
• Common (1% to 10%): Rash, abnormal hair growth^[Ref]

Metabolic

• Very common (10% or more): Hyperglycemia (51%), dysgeusia (46%), decreased weight (30%), decreased appetite (23%)
• Common (1% to 10%): Dehydration^[Ref]

Nervous system

• Very common (10% or more): Dysgeusia (46%), headache (15%)^[Ref]

Gastrointestinal

• Very common (10% or more): Increased lipase (43%), nausea (39%), diarrhea (32%), abdominal pain (18%), increased amylase (16%), vomiting (11%)
• Common (1% to 10%): Dyspepsia, constipation, GI reflux^[Ref]

Other

• Very common (10% or more): Fatigue (41%), pain (14%)^[Ref]

Hematologic

• Very common (10% or more): Anemia (32%), lymphopenia (28%)^[Ref]

Hepatic

• Very common (10% or more): Increased ALT (19%), increased AST (19%)^[Ref]

Endocrine

• Frequency not reported: Amenorrhea^[Ref]

Frequently asked questions

• What are the most common skin conditions? (with photos)
• How does Odomzo work?

Further information

Sonidegib side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer