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Sonidegib Side Effects

For the Consumer

Applies to sonidegib: oral capsule

Along with its needed effects, sonidegib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sonidegib:

More common
  • Difficulty with moving
  • joint pain
  • muscle aching or cramping
  • muscle pains or stiffness
  • muscle spasms
  • swollen joints
Rare
  • Dark-colored urine
  • fever
  • muscle stiffness
  • unusual tiredness or weakness

Some side effects of sonidegib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Abdominal or stomach pain
  • change in taste
  • decreased appetite
  • decreased weight
  • diarrhea
  • hair loss or thinning of the hair
  • headache
  • itching skin
  • loss of taste
  • nausea
  • vomiting

For Healthcare Professionals

Applies to sonidegib: oral capsule

General

Adverse reactions reported in at least 2 patients that led to discontinuation of this drug were muscle spasms, dysgeusia, asthenia, increased lipase, nausea, fatigue, decreased appetite, alopecia, and decreased weight. Serious adverse reactions occurred in 18% of patients.[Ref]

Musculoskeletal

75% of patients with increased serum creatinine had levels that remained within normal range.[Ref]

Very common (10% or more): Increased serum creatinine (92%), increased serum creatinine kinase (61%), muscle spasms (54%), musculoskeletal pain (32%), myalgia (19%)
Uncommon (0.1% to 1%): Rhabdomyolysis[Ref]

Dermatologic

Very common (10% or more): Alopecia (53%), pruritus (10%)[Ref]

Metabolic

Very common (10% or more): Hyperglycemia (51%), decreased weight (30%), decreased appetite (23%)[Ref]

Nervous system

Very common (10% or more): Dysgeusia (46%), headache (15%)[Ref]

Gastrointestinal

Very common (10% or more): Increased lipase (43%), nausea (39%), diarrhea (32%), abdominal pain (18%), increased amylase (16%), vomiting (11%)[Ref]

Other

Very common (10% or more): Fatigue (41%), pain (14%)[Ref]

Hematologic

Very common (10% or more): Anemia (32%), lymphopenia (28%)[Ref]

Hepatic

Very common (10% or more): Increased ALT (19%), increased AST (19%)[Ref]

Endocrine

Frequency not reported: Amenorrhea[Ref]

References

1. "Product Information. Odomzo (sonidegib)." Novartis Pharmaceuticals, East Hanover, NJ.

Some side effects of sonidegib may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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