Medically reviewed by Drugs.com. Last updated on May 7, 2021.
Applies to the following strengths: 200 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Basal Cell Carcinoma
200 mg orally once a day until disease progression or unacceptable toxicity
-Prior to therapy initiation, serum creatinine kinase (CK) levels and renal function tests should be obtained.
-Verify pregnancy status in all patients of reproductive potential.
Use: For adult patients with locally advanced basal cell carcinoma (BCC) that has recurred following surgery or radiation therapy, or those who are not candidates for surgery or radiation therapy
Renal Dose Adjustments
No adjustment recommended.
Liver Dose Adjustments
No adjustment recommended.
For the following conditions, interrupt therapy until resolution of symptoms then resume at 200 mg/day:
-Severe or intolerable musculoskeletal adverse reactions
-First occurrence of serum CK elevation between 2.5 and 10 x ULN
-Recurrent serum CK elevation between 2.5 and 5 x ULN
Permanently discontinue therapy for the following conditions:
-Serum CK elevation greater than 2.5 x ULN with worsening renal function
-Serum CK elevation greater than 10 x ULN
-Recurrent serum CK elevation greater than 5 x ULN
-Recurrent severe or intolerable musculoskeletal adverse reactions
US BOXED WARNINGS:
-This drug can cause embryofetal death or severe birth defects when administered to a pregnant woman and is embryotoxic, fetotoxic, and teratogenic in animals.
-Verify the pregnancy status of females of reproductive potential prior to initiating therapy.
-Advise females of reproductive potential to use effective contraception during therapy and for at least 20 months after.
-Advise males of the potential risk of exposure through semen and to use condoms with a pregnant partner or a female partner of reproductive potential during therapy for at least 8 months after.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available
-This drug should be taken on an empty stomach at least 1 hour before or 2 hours after a meal.
-This drug should be taken at the same time each day.
-A missed dose should be skipped; treatment should be resumed with the next scheduled dose.
-Swallow capsules whole; do not chew or crush.
-If a dose is missed, take it within 6 hours after the missed dose. If more than 6 hours have passed, do not to take the missed dose.
-Embryofetal Toxicity: Pregnancy test (before treatment initiation)
-Musculoskeletal: Baseline serum CK and creatinine levels (before treatment initiation, periodically during treatment, and as clinically indicated; at least weekly during treatment in patients with musculoskeletal adverse reactions with concurrent serum CK elevations greater than 2.5 x ULN)
-Renal: Renal function tests (before treatment initiation)
-This drug can interact with a variety of medications. Tell your doctor about all the medications you take, including prescription and over-the-counter drugs, vitamins, dietary and herbal supplements.
Frequently asked questions
More about sonidegib
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