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Signifor LAR Side Effects

Generic name: pasireotide

Medically reviewed by Drugs.com. Last updated on Mar 12, 2024.

Note: This document provides detailed information about Signifor LAR Side Effects associated with pasireotide. Some dosage forms listed on this page may not apply specifically to the brand name Signifor LAR.

Applies to pasireotide: powder for suspension, solution.

Serious side effects of Signifor LAR

Along with its needed effects, pasireotide (the active ingredient contained in Signifor LAR) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking pasireotide:

More common

  • anxiety
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blurred vision
  • chills
  • cold sweat
  • confusion
  • cool, pale skin
  • darkening of the skin
  • decreased urine
  • depression
  • diarrhea
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fainting
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • loss of appetite
  • loss of consciousness
  • muscle pain or cramps
  • nausea
  • nightmares
  • numbness or tingling in the hands, feet, or lips
  • pounding in the ears
  • rapid weight gain
  • recurrent fever
  • seizures
  • shakiness
  • skin rash
  • slow, fast, or irregular heartbeat
  • slurred speech
  • stomach pain or fullness
  • sweating
  • tingling of the hands or feet
  • trouble breathing
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting
  • yellow eyes or skin

Incidence not known

  • clay-colored stools
  • constipation
  • darkened urine
  • dry skin and hair
  • feeling cold
  • fever
  • hair loss
  • hoarseness or husky voice
  • indigestion
  • itching
  • loss of appetite
  • muscle stiffness
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • unpleasant breath odor
  • vomiting of blood

Other side effects of Signifor LAR

Some side effects of pasireotide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • back pain
  • bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • cough
  • difficulty with moving
  • feeling of constant movement of self or surroundings
  • general feeling of discomfort or illness
  • joint pain
  • lack or loss of strength
  • pain in the arms or legs
  • sensation of spinning
  • shivering
  • stuffy or runny nose
  • swollen joints
  • trouble sleeping

For healthcare professionals

Applies to pasireotide: intramuscular powder for injection extended release, subcutaneous solution.

General

Dermatologic

Endocrine

Gastrointestinal

Cardiovascular

Hematologic

Hepatic

Local

Metabolic

Musculoskeletal

Nervous system

Respiratory

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

2. Cerner Multum, Inc. "Australian Product Information."

3. (2013) "Product Information. Signifor (pasireotide)." Novartis Pharmaceuticals

Further information

Signifor LAR side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.