Sansert Side Effects

Generic name: methysergide maleate

Note: This document provides detailed information about Sansert Side Effects associated with methysergide maleate. Some dosage forms listed on this page may not apply specifically to the brand name Sansert.

Applies to methysergide maleate: oral tablet.

Precautions

If you have been taking this medicine regularly, do not stop taking it without first checking with your doctor. Your doctor may want you to reduce gradually the amount you are using before stopping completely. If you stop taking it suddenly, your headaches may return or worsen.

Your doctor will tell you how long you should take this medicine. Usually it is not taken for longer than 6 months at a time. If the doctor tells you to stop taking the medicine for a while, do not continue to take it. If your body does not get a rest from the medicine, it can have harmful effects.

This medicine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert .

If dizziness occurs, get up slowly after lying or sitting down. If the problem continues or gets worse, check with your doctor.

Since drinking alcoholic beverages may make headaches worse, it is best to avoid alcohol while you are suffering from them. If you have any questions about this, check with your doctor.

Since smoking may increase some of the harmful effects of this medicine, it is best to avoid smoking while you are using it. If you have any questions about this, check with your doctor.

This medicine may make you more sensitive to cold temperatures, especially if you have blood circulation problems. It tends to decrease blood circulation in the skin, fingers, and toes. Dress warmly during cold weather and be careful during prolonged exposure to cold, such as in winter sports. This is especially important for elderly people, who are more likely than younger adults to already have problems with their circulation.

Check with your doctor if a serious infection or illness of any kind occurs while you are taking methysergide, since an infection may make you more sensitive to the medicine's effects.

Serious side effects of Sansert

Along with its needed effects, methysergide maleate (the active ingredient contained in Sansert) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking methysergide maleate:

• chest pain or tightness in chest
• convulsions (seizures)
• difficult or painful urination
• dizziness (severe)
• fever or chills
• increase or decrease (large) in the amount of urine
• leg cramps
• pain in arms, legs, groin, lower back, or side
• pale or cold hands or feet
• shortness of breath or difficult breathing
• swelling of hands, ankles, feet, or lower legs

Check with your doctor as soon as possible if any of the following side effects occur while taking methysergide maleate:

Other side effects of Sansert

Some side effects of methysergide maleate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

After you stop using this medicine, your body may need time to adjust. The length of time this takes depends on the amount of medicine you were using and how long you used it. During this time check with your doctor if your headaches begin again or worsen.

See also:

For healthcare professionals

Applies to methysergide maleate: oral tablet.

General adverse events

General side effects including fibrotic changes have been reported in the retroperitoneal, pleuropulmonary, cardiac, and other tissues. Retroperitoneal fibrosis is usually confined to the retroperitoneal connective tissue above the pelvic brim and may present with symptoms of malaise, fatigue, weight loss, backache, low grade fever, urinary obstruction, and vascular insufficiency. Several cases of fibrotic plaques, simulating Peyronie's disease have also been reported.^[Ref]

Respiratory

Respiratory side effects including fibrosis limited to the pleural and subjacent pulmonary tissues has been reported. In such instances, patients usually present with dyspnea, tightness and pain in the chest, pleural friction rubs, and pleural effusion.^[Ref]

Cardiovascular

Cardiovascular side effects including fibrotic changes such as nonrheumatic thickening of the aortic root and aortic and mitral valves have been reported. Encroachment of retroperitoneal fibrosis on the aorta, inferior vena cava and their common iliac branches may result in vascular insufficiency of the lower limbs. Intrinsic vasoconstriction of large and small arteries may occur at any stage of therapy. Progression to ischemic tissue damage has rarely been reported.

Postural hypotension and tachycardia have also been reported.^[Ref]

Gastrointestinal

Gastrointestinal symptoms including nausea, vomiting, diarrhea, heartburn, constipation, elevated gastric acid, and abdominal pain have been reported.^[Ref]

Nervous system

Nervous system side effects have included seizure, insomnia, drowsiness, mild euphoria, dizziness, ataxia, lightheadedness, hyperesthesia, and feelings of dissociation or hallucinations.^[Ref]

Dermatologic

Dermatologic side effects including facial flushing, telangiectasia, and nonspecific rashes have been reported rarely. Increased hair loss may also occur.^[Ref]

Hematologic

Hematologic side effects have included neutropenia, eosinophilia, and thrombocytopenia.^[Ref]

Musculoskeletal

Musculoskeletal side effects including arthralgia and myalgia have been reported.^[Ref]

Ocular

Ocular side effects including mydriasis have been reported.^[Ref]

Other

Other side effects have included peripheral edema, weakness, weight gain, and fever.^[Ref]

Further information

Sansert side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer