Ryzodeg 70 / 30 Side Effects
Generic name: insulin aspart / insulin degludec
Note: This document contains side effect information about insulin aspart / insulin degludec. Some of the dosage forms listed on this page may not apply to the brand name Ryzodeg 70 / 30.
Weight gain, attributed to the anabolic effects of insulin, has been reported. In clinical trials, an average weight gain of 1.6 kg and 2.8 kg was reported in patients with type 1 diabetes and type 2 diabetes, respectively.[Ref]
Very common (10% or more): Hypoglycemia (up to 95%)
Frequency not reported: Weight gain[Ref]
Common (1% to 10%): Influenza
The detection of antibodies is dependent on the sensitivity and specificity of the assay and may be influenced by several factors such as assay methodology, sample handling, timing of sample collection, concomitant medications, and underlying disease. Therefore, comparison of the incidence of antibodies may be misleading. In a study in insulin-experienced patients with type 1 diabetes receiving insulin degludec/insulin aspart, 13% were positive for anti-insulin aspart antibodies at least once during the study, including 6.4% who were positive at baseline. For insulin degludec, in adult insulin experienced type 1 diabetes patients, 63.5% of patients receiving this insulin were positive at baseline for anti-insulin degludec antibodies and 15.4% developed anti-insulin degludec antibodies at least once during the study. In immunogenic trials, 99.4% to 100% of patients who were positive for anti-insulin degludec antibodies were also positive for anti-human insulin antibodies.[Ref]
In clinical trials, peripheral edema was reported in 2.2% and 1.8% of patients with type 1 diabetes and type 2 diabetes, respectively.[Ref]
Common (1% to 10%): Peripheral edema[Ref]
Common (1% to 10%): Injection site reactions including hematoma, pain, hemorrhage, erythema, nodules, swelling, discoloration, pruritus, warmth, and injection site mass
Uncommon (0.1% to 1%): Lipodystrophy[Ref]
Very common (10% or more): Nasopharyngitis (up to 24.6%)
Common (1% to 10%): Headache
Medically reviewed by Drugs.com. Last updated on Mar 19, 2021.
Frequently asked questions
More about Ryzodeg 70 / 30 (insulin aspart / insulin degludec)
- During Pregnancy
- Dosage Information
- Drug Interactions
- 2 Reviews
- Drug class: insulin
- FDA Approval History
Related treatment guides
1. "Product Information. Ryzodeg 70 / 30 FlexTouch (insulin aspart-insulin degludec)." Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
Some side effects may not be reported. You may report them to the FDA.