Rezurock Side Effects

Generic name: belumosudil

Medically reviewed by Drugs.com. Last updated on Nov 13, 2024.

Note: This document provides detailed information about Rezurock.

Applies to belumosudil: oral tablet Side Effects associated with belumosudil. Some dosage forms listed on this page may not apply specifically to the brand name Rezurock.

Applies to belumosudil: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to see if the medicine is working properly and to decide if you should continue to take it. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting treatment. Women should use an effective form of birth control during treatment and for 1 week after the last dose. Men should use an effective form of birth control during treatment and for 1 week after the last dose to prevent pregnancy in a sexual partner. If you think a pregnancy has occurred with this medicine, tell your doctor right away.

This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Rezurock

Along with its needed effects, belumosudil (the active ingredient contained in Rezurock) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking belumosudil:

Other side effects of Rezurock

Some side effects of belumosudil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to belumosudil: oral tablet.

General adverse events

The most common adverse reactions occurring in 20% or more patients, including laboratory abnormalities, were infections, asthenia, nausea, diarrhea, dyspnea, cough, edema, hemorrhage, abdominal pain, musculoskeletal pain, headache, decreased phosphate, increased gamma-glutamyl transferase, decreased lymphocytes, and hypertension.^[Ref]

Cardiovascular

• Very common (10% or more): Hypertension (up to 21%)^[Ref]

Dermatologic

• Very common (10% or more): Rash (up to 12%), pruritus/generalized pruritus (11%)^[Ref]

Rash includes maculopapular rash, erythematous rash, generalized rash, and exfoliative dermatitis.^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea/vomiting (up to 42%), diarrhea (up to 35%), upper/lower abdominal pain (up to 22%), dysphasia (up to 16%)
• Common (1% to 10%): Constipation^[Ref]

Hematologic

• Very common (10% or more): Hemorrhage (up to 23%), decreased neutrophil count (up to 83%), decreased platelets (up to 82%), decreased hemoglobin (up to 79%), decreased lymphocytes (up to 62%)^[Ref]

Hemorrhage includes contusion, hematoma, epistaxis, increased tendency to bruise, conjunctival hemorrhage, hematochezia, mouth hemorrhage, catheter site hemorrhage, hematuria, hemothorax, and purpura.^[Ref]

Hepatic

• Very common (10% or more): Increased gamma-glutamyl transferase (up to 47%)
• Common (1% to 10%): Increased AST, increased ALT^[Ref]

Metabolic

• Very common (10% or more): Decreased appetite (up to 17%)^[Ref]

Musculoskeletal

• Very common (10% or more): Musculoskeletal pain (up to 22%), arthralgia (up to 15%)
• Common (1% to 10%): Muscle spasm^[Ref]

Musculoskeletal pain includes pain in extremity, back pain, flank pain, limb discomfort, musculoskeletal chest pain, and neck pain.^[Ref]

Nervous system

• Very common (10% or more): Headache/migraine (up to 21%)
• Common (1% to 10%): Peripheral neuropathy, dizziness^[Ref]

Other

• Very common (10% or more): Decreased calcium (up to 82%), increased potassium (up to 82%), increased alkaline phosphatase (up to 80%), decreased phosphate (up to 76%), asthenia/fatigue/malaise (up to 46%), edema (up to 27%), pyrexia (up to 18%), infection (unspecified pathogen) (up to 53%), viral infection (up to 19%), bacterial infection (up to 16%)^[Ref]

Edema includes peripheral edema, generalized edema, face edema, and localized edema.

Infection with unspecified pathogens includes acute sinusitis, device-related infection, ear infection, folliculitis, gastroenteritis, gastrointestinal infection, hordeolum, infectious colitis, lung infection, skin infection, tooth infection, urinary tract infection, wound infection, upper respiratory tract infection, pneumonia, conjunctivitis, sinusitis, respiratory tract infection, bronchitis, sepsis, and septic shock.

Viral infection includes influenza, rhinovirus infection, gastroenteritis viral, viral upper respiratory tract infection, bronchitis viral, Epstein-Barr viremia, Epstein-Barr virus infection, parainfluenza virus infection, and Varicella zoster virus infection.

Bacterial infection includes cellulitis, Helicobacter infection, Staphylococcal bacteremia, catheter site cellulitis, Clostridium difficile colitis, Escherichia urinary tract infection, gastroenteritis Escherichia coli, Pseudomonas infection, and bacterial urinary tract infection.^[Ref]

Renal

• Very common (10% or more): Increased creatinine (up to 83%)^[Ref]

Respiratory

• Very common (10% or more): Dyspnea (up to 33%), cough/productive cough (up to 30%), nasal congestion (up to 12%)^[Ref]

Dyspnea includes exertional dyspnea, apnea, orthopnea, and sleep apnea syndrome.^[Ref]

See also:

Further information

Rezurock side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer