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Revcovi Side Effects

Generic name: elapegademase

Medically reviewed by Last updated on Jul 21, 2023.

Note: This document contains side effect information about elapegademase. Some dosage forms listed on this page may not apply to the brand name Revcovi.

Applies to elapegademase: intramuscular solution.

Serious side effects of Revcovi

Along with its needed effects, elapegademase (the active ingredient contained in Revcovi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking elapegademase:


Incidence not known

Other side effects of Revcovi

Some side effects of elapegademase may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


Incidence not known

For Healthcare Professionals

Applies to elapegademase: intramuscular solution.


Very common (10% or more): Lymphadenopathy (16%)

Postmarketing reports: Hemolytic anemia, autoimmune hemolytic anemia, thrombocythemia, autoimmune thrombocytopenia[Ref]


Very common (10% or more): Influenza (16%), stoma site infection (16%)

Frequency not reported: Immunogenicity[Ref]


Postmarketing reports: Injection site erythema[Ref]


Very common (10% or more): Arthralgia (16%)[Ref]


Very common (10% or more): Conjunctivitis (16%)[Ref]


Very common (10% or more): Injection site discomfort (16%), laceration (16%)[Ref]


Very common (10% or more): Groin abscess (16%)[Ref]


Postmarketing reports: Lymphomas[Ref]


Very common (10% or more): Cough (50%), productive cough (16%), epistaxis (16%), pulmonary haemophilus infection (16%), hemoptysis (16%), nasal edema (16%), upper respiratory tract infection (16%)[Ref]


Very common (10% or more): Fatigue (16%), cerumen impaction (16%), ear canal irritation (16%), ear lobe infection (16%), otitis externa (16%)[Ref]


The most common adverse effects were cough (50%) and vomiting (33%)[Ref]

Nervous system

Very common (10% or more): Asthenia (16%), convulsion (16%), gait disturbance (16%), migraine (16%)[Ref]


Very common (10% or more): Nephrolithiasis (16%)[Ref]


Very common (10% or more): Fungal skin infection (16%), rash (16%), face swelling (16%)

Postmarketing reports: Urticaria[Ref]


Very common (10% or more): Vomiting (33%), abdominal pain upper (16%), dental caries (16%), tooth abscess (16%), tooth extraction (16%), diarrhea (16%), GI infection (16%), hematochezia (16%), nausea (16%), oral candidiasis (16%), oropharyngeal pain (16%)[Ref]

Frequently asked questions


1. Product Information. Revcovi (elapegademase). Leadiant Biosciences, Inc. 2018.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.