Elapegademase Levels and Effects while Breastfeeding
Summary of Use during Lactation
No information is available on the use of elapegademase during breastfeeding. Because elapegademase is a large protein molecule with a molecular weight of about 113,000 Da, the amount in milk is likely to be very low.[1] It is also likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal.[2] If elapegademase is required by the mother, it is not a reason to discontinue breastfeeding. Until more data are available, elapegademase should be used with careful monitoring during breastfeeding. Waiting for at least 2 weeks postpartum to resume therapy may minimize transfer to the infant.[3]
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
1.
Stratigakis A, Paty D, Zou P, et al. A regression approach for assessing large molecular drug concentration in breast milk. Reprod Breed 2023;3:199-207. doi:10.1016/j.repbre.2023.10.003 [CrossRef]
2.
Anderson PO. Monoclonal antibodies during breastfeeding. Breastfeed Med 2021;16:591-3. [PubMed: 33956488]
3.
Krysko KM, Dobson R, Alroughani R, et al. Family planning considerations in people with multiple sclerosis. Lancet Neurol 2023;22:350-66. [PubMed: 36931808]
Substance Identification
Substance Name
Elapegademase
CAS Registry Number
1709806-75-6
Drug Class
Breast Feeding
Lactation
Milk, Human
Enzymes
Enzyme Replacement Therapy
Adenosine Deaminase Inhibitors
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.