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Generic name: elapegademaseEL-a-peg-AD-e-mase ]
Drug class: Other immunostimulants

Medically reviewed by on Jan 2, 2023. Written by Cerner Multum.

What is Revcovi?

Revcovi is a man-made form of an enzyme called adenosine deaminase (ADA). ADA is important in the body for preventing the buildup of certain proteins harmful to the white blood cells that help your body fight infections.

Revcovi is used to replace ADA in adults and children with adenosine deaminase severe combined immune deficiency (ADA-SCID).

ADA-SCID is a lack of immunity to infections that might not cause illness in someone with a healthy immune system. Certain infections (such as pneumonia, chronic diarrhea, or serious skin rash) can be serious or even fatal in people with ADA-SCID.

ADA-SCID can also slow the growth or development of an infant or young child affected with this condition.

Revcovi may also be used for purposes not listed in this medication guide.


Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

Tell your doctor if you have ever used a medication called Adagen (pegademase bovine).

Also tell your doctor if you have had severe thrombocytopenia (low levels of platelets in blood).

Your doctor should check your progress on a regular basis if you use Revcovi during pregnancy.

It may not be safe to breast-feed while using Revcovi. Ask your doctor about any risk.

How is Revcovi given?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Revcovi is injected into a muscle. A healthcare provider can teach you how to properly use the medication by yourself.

Revcovi is usually given once every 7 days. Follow your doctor's dosing instructions very carefully.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Prepare an injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

Revcovi doses are based on weight. Your dose needs may change if you gain or lose weight.

You may need frequent medical tests. Even if you have no symptoms, tests can help your doctor determine if this medicine is effective.

It may take 2 to 6 months before you receive the full benefit of using Revcovi. Keep using the medication regularly to get the most benefit.

Do not shake the medication bottle or you may ruin the medicine.

Store in the refrigerator, do not freeze. Throw away the medicine if it has become frozen.

Each vial (bottle) is for one use only. Throw it away after one use, even if there is still medicine left inside.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Revcovi?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

Revcovi side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Revcovi may cause serious side effects. Call your doctor at once if you have:

  • bleeding where the medicine was injected;

  • other unusual bleeding (nosebleeds, bleeding gums);

  • a seizure; or

  • pale or yellowed skin, dark colored urine; or

  • confusion or weakness.

The following symptoms may be signs of infection, which may indicate that Revcovi is not an effective treatment for you. Tell your doctor if you have:

  • fever, chills, unusual tiredness;

  • sore throat, sinus pain, swollen glands;

  • skin warmth or swelling;

  • stomach cramps, vomiting, or diarrhea;

  • blood in your urine or stools;

  • painful or difficult urination;

  • breathing problems, cough with mucus;

  • sores or white patches in your mouth or on your skin;

  • problems with balance or walking; or

  • problems with your teeth or gums.

Common side effects of Revcovi may include:

  • vomiting; or

  • cough.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Revcovi?

Other drugs may affect Revcovi, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Frequently asked questions

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.