Generic name: trilaciclib [ TRY-la-SYE-klib ]
Brand name: Cosela
Dosage form: intravenous powder for injection (300 mg)
Drug class: Other immunostimulants

Medically reviewed by Drugs.com on Mar 7, 2024. Written by Cerner Multum.

What is trilaciclib?

Trilaciclib is used to help prevent bone marrow suppression in people receiving chemotherapy with certain medicines to treat small cell lung cancer.

Trilaciclib may also be used for purposes not listed in this medication guide.

Trilaciclib side effects

Get emergency medical help if you have signs of an allergic reaction: hives, itching; difficult breathing; swelling of your eyes, face, lips, tongue, or throat.

Trilaciclib may cause serious side effects. Call your doctor at once if you have:

• pain, redness, warmth, itching, swelling, bruising, or skin changes where the medicine was injected;

• fever, chills, cough with mucus;

• sudden chest pain, wheezing, dry cough, feeling short of breath;

• low calcium level--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes); or

• low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.

Your trilaciclib treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of trilaciclib may include:

• low levels of calcium or potassium;

• headache;

• breathing problems;

• feeling tired; or

• abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Call your doctor at once if you have pain, redness, warmth, itching, swelling, bruising, or skin changes where the medicine was injected.

Before taking this medicine

You should not be treated with trilaciclib if you are allergic to it.

Tell your doctor if you have ever had liver problems.

Trilaciclib may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using trilaciclib and for at least 3 weeks after your last dose. Tell your doctor if you become pregnant.

You should not breastfeed while using trilaciclib and for at least 3 weeks after your last dose.

How is trilaciclib given?

Trilaciclib is given as an infusion into a vein, usually within 4 hours before the start of your chemotherapy infusion. A healthcare provider will give you this injection.

Trilaciclib must be given slowly, and the infusion can take at least 30 minutes to complete.

Trilaciclib dosing information

Usual Adult Dose for Chemotherapy Toxicity:

240 mg/m2 IV over 30-minute completed within 4 hours prior to the start of chemotherapy day

Comments:
-Interval between doses of this drug on sequential days should not be greater than 28 hours.
-For a is missed, discontinue chemotherapy that day and consider resuming both this drug and the chemotherapy on the next scheduled chemotherapy day.
-If this drug is discontinued, wait 96 hours from the last dose of this drug before resuming the chemotherapy regimen alone.

Use:
-To decrease the incidence of chemotherapy-induced myelosuppression in adult patients when administered prior to a platinum/etoposide-containing regimen or topotecan containing regimen for extensive-stage small cell lung cancer

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your trilaciclib injection.

What happens if I overdose?

Since trilaciclib is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving trilaciclib?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect trilaciclib?

Tell your doctor about all your other medicines, especially:

• cisplatin;

• dalfampridine; or

• dofetilide.

This list is not complete. Other drugs may affect trilaciclib, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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